{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T12:45:12Z","timestamp":1779281112924,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100031198","name":"Department of Health, Government of Western Australia","doi-asserted-by":"publisher","award":["RTP2018(R12)\/5"],"award-info":[{"award-number":["RTP2018(R12)\/5"]}],"id":[{"id":"10.13039\/100031198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1191465"],"award-info":[{"award-number":["1191465"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1111657"],"award-info":[{"award-number":["GNT1111657"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Evidence\u2010based recommendations exist for early discharge (before 48\u2009h) of young infants with fever without source (FWS) at low risk of serious bacterial infections (SBIs). However, concerns regarding the applicability of international data to local contexts may hinder implementation. We aimed to describe the local epidemiology of FWS and evaluate a newly implemented risk\u2010stratification guideline to support practice change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective observational study of infants aged &lt;\u20093\u2009months admitted for investigation and management of FWS to two hospitals in Perth, Western Australia following implementation of an FWS risk\u2010stratification guideline (August 2019\u2013December 2021). We assessed the risk\u2010stratification rule performance and determined the positive\/negative likelihood ratios of individual patient characteristics for predicting SBI diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five hundred infants were enrolled in the study cohort (median age 34\u2009days, 36% female). SBI was diagnosed in 159 infants (32%), including urinary tract infection (<jats:italic>n<\/jats:italic>\u2009=\u2009140), bacteraemia (<jats:italic>n<\/jats:italic>\u2009=\u200918) and bacterial meningitis (<jats:italic>n<\/jats:italic>\u2009=\u20099). Viruses were detected in 174 out of 406 tested infants (43%). Seventy\u2010one infants met low\u2010risk criteria (14%); only 69 out of 360 infants without SBI were classified as low risk (19%). The risk\u2010stratification criteria demonstrated 99% sensitivity and 97% negative predictive value for SBI diagnosis, but only 21% specificity. Patient characteristics associated with a reduced likelihood of SBI diagnosis included female sex, sick contact exposure and virus detection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Meeting the low\u2010risk criteria successfully excluded most infants with SBI; however, only a small proportion of infants without SBI fulfilled these criteria. Integrating additional patient characteristics into updated risk\u2010stratification algorithms may improve the predictive value of future prediction tools.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>Australia and New Zealand Clinical Trials Register (ACTRN12619001010189)<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.70041","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T20:01:28Z","timestamp":1743364888000},"page":"894-904","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>FeBRILe3<\/scp>: Risk\u2010Stratification and Diagnosis of Serious Bacterial Infections in Febrile Infants Less Than 3\u2009Months Old"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8621-5664","authenticated-orcid":false,"given":"Ariel O.","family":"Mace","sequence":"first","affiliation":[{"name":"Department of General 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C.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of General Paediatrics Perth Children's Hospital  Perth Western Australia Australia"},{"name":"School of Medicine The University of Western Australia  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Barnett","sequence":"additional","affiliation":[{"name":"Department of General Paediatrics Perth Children's Hospital  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jade","family":"Ferullo","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Fiona Stanley Hospital  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Briony","family":"Hazelton","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Perth Children's Hospital  Perth Western Australia Australia"},{"name":"Department of Microbiology 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