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We included a history section to better recognise the way that the scientific and medical communities have studied and understood the importance of RPRs. We review findings indicating that aspects of these disorders are related to the presence of functional disconnectivities related to a cortical maturational effect on neuronal networks. Cortical maturational delay within specific networks may lead to enhanced growth and maturation in other networks, resulting in asynchronous development and inconsistency in functional skills. There has been reported an overconnectivity of short\u2010range, more immature connections and an underconnectivity of long\u2010range, more mature connectivities. We review the relationship between motor and cognitive impairments and RPRs. A crucial conclusion will be that inhibiting these RPRs is representative of treatment targets.<\/jats:p>","DOI":"10.1111\/jpc.70053","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T12:04:38Z","timestamp":1744113878000},"page":"846-851","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Evaluating Primitive Reflexes in Early Childhood as\u00a0a Potential Biomarker for Developmental Disabilities"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9975-7331","authenticated-orcid":false,"given":"Gerry","family":"Leisman","sequence":"first","affiliation":[{"name":"Movement &amp; Cognition Laboratory, Faculty of Social Welfare and Health Sciences University of Haifa  Haifa Israel"},{"name":"Resonance Therapeutics Laboratory, Department of Neurology University of the Medical Sciences of Havana  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4405-0192","authenticated-orcid":false,"given":"Robert","family":"Melillo","sequence":"additional","affiliation":[{"name":"Movement &amp; Cognition Laboratory, Faculty of Social Welfare and Health Sciences University of Haifa  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobeha.2024.101455"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.922322"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2023.04.004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-88832-9_35"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhad458"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2020.04.002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-197303000-00020"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-0522-2_18"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(00)00185-6"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-69415-5.00094-1"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40474-021-00232-2"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurpra.2023.104767"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11080967"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/13674935221114187"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2023.1175974"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.5604\/01.3001.0053.7205"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.430685"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19074070"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2014.00016"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2016.07.010"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyg.13098"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-021-02391-3"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2005000400004"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-6231-8.10016-9"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1989.tb03707.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2024.112583"},{"issue":"1","key":"e_1_2_9_28_1","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.1153","article-title":"The Neurological Phenotype of Developmental Motor Patterns During Early Childhood","volume":"9","author":"Kuiper M. 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