{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:11:14Z","timestamp":1791231074199,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vitamin B12 is a vital vitamin essential for DNA synthesis, central nervous system myelination and erythropoiesis. Its deficiency, particularly during the rapid growth phase of infancy, can lead to neurological and haematological complications. This study aimed to investigate the relationship between vitamin B12 deficiency, hemogram parameters, and thyroid hormones in children under 36\u2009months of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials &amp; Methods<\/jats:title><jats:p>Conducted at Bilkent Children's Hospital between 2020 and 2024, the study evaluated 10\u2009268 children, grouped based on their B12 levels (\u2264\u2009200\u2009pg\/mL: deficient, 200\u2013800\u2009pg\/mL: normal).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Vitamin B12 deficiency was identified in 7.8% of the participants, with the highest prevalence (12.3%) in the 0\u201312\u2009months age group. In the deficiency group, WBC, NEU, NEU\/LYM ratio, HGB and TSH levels were found to be lower, while PLT levels were higher. Neutropenia was found to be significantly more frequent in the low B12 group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). No significant difference was found in the prevalence of lymphopenia and leukopenia between the groups. Regarding thyroid hormone levels, fT4 levels were similar across groups, but TSH levels were lower in the B12\u2010deficient group. A positive correlation was observed between TSH and HGB levels, while a negative correlation was noted with the NEU\/LYM ratio.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, B12 deficiency during infancy can cause significant changes in hemogram parameters. During this period, when physiological anaemia is common, MCV may remain normal. Neutropenia and a lower Neu\/Lym ratio appear to be the most striking hemogram parameters associated with vitamin B12 deficiency in infants undergoing routine check\u2010ups. Decreased TSH levels may be related to B12 deficiency, and the NEU\/LYM ratio could serve as a predictor of thyroid dysfunction. This study stands out as a large\u2010scale study demonstrating the effects of B12 deficiency on haematological and thyroid parameters.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.70065","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T10:44:31Z","timestamp":1745318671000},"page":"1030-1038","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of Vitamin <scp>B12<\/scp> Deficiency on Hemogram Parameters and Its Relationship With Thyroid Hormones in Infancy"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8014-4743","authenticated-orcid":false,"given":"B\u00fc\u015fra","family":"Demirci","sequence":"first","affiliation":[{"name":"Department of Pediatrics Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2334-9590","authenticated-orcid":false,"given":"Dilek","family":"Konuksever","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5273-9371","authenticated-orcid":false,"given":"G\u00fcl\u015fah Efeo\u011flu","family":"G\u00fclsoy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5768-3549","authenticated-orcid":false,"given":"Sevin\u00e7 P\u00fcren","family":"Y\u00fccel","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Cukurova University  Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.40"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15234960"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2016.09.013"},{"key":"e_1_2_9_5_1","volume-title":"Lanzkowsky's Manual of Pediatric Hematology and Oncology","author":"Fish J. 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C.","year":"2020","journal-title":"Northern Clinics of Istanbul"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830090110"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1179\/1476830515Y.0000000041"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-1252"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.04.023"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2010.04.005"},{"key":"e_1_2_9_18_1","article-title":"Association Between the Systemic Immune\u2010Inflammation Index and Thyroid Function in U.S. Adults","volume":"1","author":"Hu X. 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