{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:10:13Z","timestamp":1792030213100,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Montelukast is a leukotriene receptor antagonist commonly used in allergic diseases. In this study, we investigated the frequency, severity and risk factors for neuropsychiatric side effects and sleep disorders associated with montelukast in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Children aged 6\u2009months to 17\u2009years prescribed montelukast for allergic rhinitis or asthma at 31 Paediatric Allergy and Immunology centres were enrolled in this cohort study. At enrollment, sociodemographic characteristics, prior diagnoses of neuropsychiatric diseases or sleep disorders, and indications for montelukast treatment were recorded, and the primary caregivers completed a baseline questionnaire about neuropsychiatric symptoms (insomnia, nightmares and depressed mood) of their children. All participants were followed up for 1\u2009month, and a post\u2010treatment follow\u2010up questionnaire on neuropsychiatric symptoms was completed at the end of this period. Moreover, caregivers were instructed to contact the clinic if neuropsychiatric side effects or sleep disorders were observed during this period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total of 1163 children were enrolled. There was a significant increase in the frequency of insomnia, nightmares, night terrors, drowsiness, behavioural problems, irritability, depressive mood, agitation, anxiety, hyperactivity, learning difficulties and headache during the 1\u2009month period after montelukast treatment compared to the previous 1\u2009month (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 for all). Overall, caregiver reports of neuropsychiatric symptoms in children increased from 172 (14.8%) to 399 (34.3%) after 1\u2009month of montelukast treatment (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Montelukast treatment increases the risk of neuropsychiatric symptoms and sleep disorders in children with allergic diseases, especially if there is concomitant use of antihistamines.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.70092","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T01:48:58Z","timestamp":1749520138000},"page":"1287-1294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Potentially Overlooked Risk for Neuropsychiatric Symptoms in Children: Montelukast Treatment"],"prefix":"10.1111","volume":"61","author":[{"given":"Seda","family":"Tunca","sequence":"first","affiliation":[{"name":"Pediatric Allergy and Immunology Celal Bayar University Faculty of Medicine  Manisa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6051-5020","authenticated-orcid":false,"given":"Ozge","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Celal Bayar University Faculty of Medicine  Manisa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merve","family":"Ocalan","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Celal Bayar University Faculty of Medicine  Manisa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Arga","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Istanbul Medeniyet University Faculty of Medicine  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozlem","family":"Cavkaytar","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Istanbul Medeniyet University Faculty of Medicine  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Ozceker","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Istanbul Prof. Dr. Cemil Ta\u015f\u00e7\u0131o\u011flu City Hospital  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Kili\u00e7","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Firat University Hospital  Elazig Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6067-3424","authenticated-orcid":false,"given":"Fatma","family":"Duksal","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Konya City Hospital  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demet","family":"Can","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Beh\u00e7et Uz Children's Hospital  \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2489-4021","authenticated-orcid":false,"given":"Ozlem","family":"Sancakli","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Beh\u00e7et Uz Children's Hospital  \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet \u015eirin","family":"Kaya","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Beh\u00e7et Uz Children's Hospital  \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazli","family":"Ercan","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology SBU G\u00fclhane Training and Research Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nursen Cigerci","family":"Gunaydin","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Tekirda\u011f Nam\u0131k Kemal University Faculty of Medicine  Merkez Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metin","family":"Aydogan","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Kocaeli University Faculty of Medicine  Kocaeli Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esen","family":"Demir","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Ege University Faculty of Medicine  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Recep","family":"Sancak","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Ondokuz May\u0131s University Faculty of Medicine  Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sefika \u0130lknur K\u00f6kc\u00fc","family":"Karadag","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Ondokuz May\u0131s University Faculty of Medicine  Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihat","family":"Sapan","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Uluda\u011f University Faculty of Medicine  Bursa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet Ugur","family":"Demir","sequence":"additional","affiliation":[{"name":"Chest Diseases Hacettepe University Faculty of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oznur","family":"Bilac","sequence":"additional","affiliation":[{"name":"Child Psychiatry Celal Bayar University Faculty of Medicine  Manisa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine Dibek","family":"Misirlioglu","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Ankara City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Turkeli","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology K\u00fctahya SBU Evliya \u00c7elebi Training and Research Hospital  K\u00fctahya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasibe","family":"Artac","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Konya Selcuk University Faculty of Medicine  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatice Eke","family":"Gungor","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Kayseri City Hospital  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haluk","family":"Cokugras","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Istanbul University Cerrahpasa Medical Faculty Hospital  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fazil","family":"Orhan","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Karadeniz Technical University Faculty of Medicine  Trabzon Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysen","family":"Bingol","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Akdeniz University Faculty of Medicine  Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinar","family":"Uysal","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Aydin Adnan Menderes University Faculty of Medicine  Ayd\u0131n Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sennur","family":"Keles","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology SBU Antalya Training and Research Hospital  Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aylin Kont","family":"Ozhan","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Mersin University Faculty of Medicine  Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuba","family":"Tuncel","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Izmir Katip Celebi University Tepecik Training and Research Hospital  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozlem","family":"Keskin","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Gaziantep University \u015eahinbey Research and Application Hospital  Gaziantep Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7319-8535","authenticated-orcid":false,"given":"Elif","family":"Arik","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Gaziantep University \u015eahinbey Research and Application Hospital  Gaziantep Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5338-9561","authenticated-orcid":false,"given":"\u00d6ner","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Sakarya University Training and Research Hospital  Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7810-7105","authenticated-orcid":false,"given":"Ceren","family":"Can","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Bak\u0131rk\u00f6y Dr. Sadi Konuk Training and Research Hospital  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazan","family":"Altinel","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Bak\u0131rk\u00f6y Dr. Sadi Konuk Training and Research Hospital  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koray","family":"Harmanci","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Eski\u015fehir Osmangazi University Faculty of Medicine  Eskisehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurda","family":"Simsek","sequence":"additional","affiliation":[{"name":"Bursa Private Practice\u2014Yurda \u015eim\u015fek  Bursa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derya Ufuk","family":"Altintas","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology \u00c7ukurova University Faculty of Medicine  Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serap","family":"Ozmen","sequence":"additional","affiliation":[{"name":"Dr Sami Ulus Obstetrics and Gynecology Child Health and Diseases Education Ar\u015f Child Allergy and Immunology  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevin","family":"Uzuner","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Dokuz Eyl\u00fcl University Faculty of Medicine  \u0130zmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yakup","family":"Can\u0131tez","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Uluda\u011f University Faculty of Medicine  Bursa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Y\u00fcksel","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Celal Bayar University Faculty of Medicine  Manisa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.09.001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.5.3.679"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2020.11.009"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2024.05.026"},{"issue":"2","key":"e_1_2_8_6_1","first-page":"64","article-title":"Joint Statement on FDA Investigation of SINGULAIR from the ACAAI and AAAAI","volume":"40","author":"Sampson L.","year":"2008","journal-title":"European Annals of Allergy and Clinical Immunology"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2001.00969.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.13643"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax\u20102024\u2010221590"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.5414\/CP204560"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61317-8"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00148-2017"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo-2021-001206"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj\u20102021\u2010067554"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1794"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-015-0360-2"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.341"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.04.035"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2019.02.009"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00092812"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12986"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.70092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T08:02:07Z","timestamp":1756540927000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.70092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,9]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/jpc.70092"],"URL":"https:\/\/doi.org\/10.1111\/jpc.70092","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"value":"1034-4810","type":"print"},{"value":"1440-1754","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,9]]},"assertion":[{"value":"2025-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}