{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:11:51Z","timestamp":1758672711699,"version":"3.44.0"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the prevalence of Vitamin D (VD) deficiency in children with Eosinophilic Oesophagitis (EoE) compared to controls and to analyse the relationship between VD status and EoE treatment outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective case\u2013control study. Children with EoE who had available VD data at the time of EoE diagnosis were included in the study group. Age\u2010 and sex\u2010matched controls were sourced from endoscopic records of children without EoE. The prevalence of VD deficiency in the two groups was calculated and compared using three cut\u2010off values for deficiency (&lt;\u200950, &lt;\u200975 and\u2009&lt;\u2009100\u2009nmol\/L). The study also examined the correlation between VD levels at diagnosis and EoE treatment response, and the relationship between EoE treatment and follow\u2010up VD levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our study showed no significant difference in the mean VD levels between the EoE (<jats:italic>n<\/jats:italic>\u2009=\u2009106) and control (<jats:italic>n<\/jats:italic>\u2009=\u2009212) groups. Among VD\u2010deficient patients with EoE (&lt;\u200950\u2009nmol\/L), higher VD levels were significantly correlated with a lower number of eosinophils per high power field (<jats:italic>R<\/jats:italic>\u2009=\u20090.58, <jats:italic>p<\/jats:italic>\u2009=\u20090.028) post\u2010treatment of EoE. Moreover, post\u2010treatment patients with EoE (not on VD supplementation) had improved VD levels compared to levels at diagnosis (<jats:italic>p<\/jats:italic>\u2009=\u20090.049).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this study, higher VD levels were associated with a greater reduction in eosinophil count with treatment in VD\u2010deficient patients with EoE. This finding raises the possibility of a beneficial role for VD supplementation in improving treatment outcomes in VD\u2010deficient patients with EoE. Further prospective studies are warranted to confirm these observations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.70126","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T01:49:47Z","timestamp":1750816187000},"page":"1407-1414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of Vitamin D in Eosinophilic Esophagitis in Children"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5009-4895","authenticated-orcid":false,"given":"Zu Zu Kyaw","family":"Lwin","sequence":"first","affiliation":[{"name":"University of New South Wales  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven T.","family":"Leach","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Sydney Children's Hospital  Sydney Australia"},{"name":"School of Clinical Medicine University of New South Wales  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usha","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Sydney Children's Hospital  Sydney Australia"},{"name":"School of Women's and Children's Health University of New South Wales  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-018-0287-0"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.06.005"},{"key":"e_1_2_11_4_1","first-page":"723","article-title":"Eosinophilic Oesophagitis \u2013 A Guide for Primary Care","volume":"44","author":"Yaxley J. 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