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Recommendations were developed using GRADE methodology and revised after a period of external consultation.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The literature search identified 26\u2009467 citations with 431 included in 41 recommendations providing 11 new and 7 key updates. The key changes included: (i) refinement of the clinical features of bronchiolitis, (ii) addition of new risk factors for severity of illness, (iii) advice on the role of biomarkers for unexpected deterioration or admission to ICU, (iv) guidance on glucocorticoids in SARS\u2010CoV\u20102 co\u2010infection, (v) guidance on combined glucocorticoids\/inhaled epinephrine in severe bronchiolitis requiring ICU level care, (vi) refinement of oxygen saturation targets, (vii) guidance on humidified high flow therapy and continuous positive airway pressure, (viii) recommendation on use of RSV prevention therapies\/immunisations for babies and mothers.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The updated Australasian Bronchiolitis Guideline provides clinicians across Australasian settings with the latest evidence\u2010based guidance on the management of the commonest condition in infancy requiring hospital admission.<\/jats:p>\n 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