{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:55:22Z","timestamp":1781528122807,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To determine the clinical characteristics and management outcomes of vitamin C deficiency in a paediatric tertiary hospital cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective review of all serum vitamin C tests from August 2020 to January 2023 at a tertiary paediatric centre. Vitamin C deficiency was defined as &lt;\u200940\u2009\u03bcmol\/L, with \u2264\u200910\u2009\u03bcmol\/L as critically deficient. Demographics, clinical indications, interventions and follow\u2010up results were analysed using descriptive statistics, chi\u2010square tests, Mann\u2013Whitney U tests and logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From 1923 tests in 1350 patients (median age 8.4\u2009years, 58.5% male), 25.2% were deficient (&lt;\u200940\u2009\u03bcmol\/L) and 5.4% critically low (\u2264\u200910\u2009\u03bcmol\/L). Inpatients and older children had higher deficiency rates (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Oncology and renal specialties demonstrated the highest deficiency yields. Age, inpatient status and oncology referrals independently predicted deficiency. Clinical indications included suspected scurvy symptoms (29%, deficiency yield 25.8%), routine screening (21%; yield 31.5%) and unclear reasons (49%; 22.2% yield). For patients with critical vitamin C deficiency (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200986), oral vitamin C supplementation was most common (69%) and follow\u2010up levels (available in 47%) showed improvement in 90%, with normalisation in 62.5%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vitamin C deficiency was common in this paediatric cohort. Improved clinical vigilance, clearer documentation of test rationale and consistent follow\u2010up practices could optimise outcomes for affected children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jpc.70158","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T10:33:56Z","timestamp":1753439636000},"page":"1630-1636","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vitamin C Deficiency in Children: Clinical Characteristics, Testing Patterns and Management Outcomes at a Tertiary Paediatric Hospital"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3727-200X","authenticated-orcid":false,"given":"Thomas","family":"McFinnegan","sequence":"first","affiliation":[{"name":"The Children's Hospital at Westmead  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Anderson","sequence":"additional","affiliation":[{"name":"The Children's Hospital at Westmead  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1398-7495","authenticated-orcid":false,"given":"Jacqueline","family":"Dalby\u2010Payne","sequence":"additional","affiliation":[{"name":"The Children's Hospital at Westmead  Sydney Australia"},{"name":"The Children's Hospital at Westmead Clinical School, Sydney Medical School The University of Sydney  Westmead Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7385-0474","authenticated-orcid":false,"given":"Jason","family":"Chung","sequence":"additional","affiliation":[{"name":"The Children's Hospital at Westmead  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14030684"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedhc.2008.10.008"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/hpeds.2023-007336"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.2003.00093.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/20469047.2023.2262787"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-016-3726-4"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2024-065782"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/scd.12459"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.16594"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-020-2341-z"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.981908"},{"issue":"126","key":"e_1_2_11_13_1","first-page":"2","article-title":"Pediatric Scurvy: When Contemporary Eating Habits Bring Back the Past","volume":"6","author":"Brambilla A.","year":"2018","journal-title":"Frontiers in Pediatrics"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2018-2824"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOSGlobal-D-24-00162"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2020.03.002"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-024-06303-x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14143378"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0379572119848287"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8110681"},{"issue":"3","key":"e_1_2_11_21_1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2223\/JPED.1984","article-title":"The History of Infant Nutrition","volume":"86","author":"Castilho S. 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