{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T11:11:28Z","timestamp":1771326688409,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Enterococci can cause serious infections in children, such as bloodstream infections. The aim of this study was to analyse the antibiotic resistance patterns of enterococci, identify associated risk factors, guide appropriate treatment strategies and evaluate the impact on clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective observational study was conducted at a tertiary\u2010level university hospital in T\u00fcrkiye and included patients under 18\u2009years of age who were diagnosed with enterococcal bacteremia between January 2013 and May 2023. All positive\n                      <jats:italic>Enterococcus<\/jats:italic>\n                      spp. blood cultures were evaluated, and contaminated and clinically insignificant blood cultures were excluded. Analyses and comparisons were made of ampicillin and vancomycin resistance profiles, clinical outcomes of healthcare\u2010associated infection (HAI) and community\u2010acquired infection (CAI) and antimicrobial resistance trends were documented throughout the study period.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In a total of 98 enterococcal bloodstream infections,\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>E. faecium<\/jats:italic>\n                      <\/jats:styled-content>\n                      was the most common species (40.8%), and the resistance rates to ampicillin and vancomycin among all enterococci were 52% and 12.2%, respectively. In the multivariate model, the odds ratio of ampicillin resistance was higher in those with non\u2010neonatal infection [odds ratio (OR): 6.098; 95% confidence interval (CI): 1.034\u201335.958;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.046], prior antibiotic use (OR: 5.013; 95% CI: 1.497\u201316.787;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009), persistent bacteremia (OR: 8.204; 95% CI: 1.028\u201365.475;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047) and inappropriate initial treatment (OR: 11.252; 95% CI: 3.288\u201338.504;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The study findings indicated that antibiotic resistance did not impact clinical outcomes; although the number of vancomycin\u2010resistant enterococci (VRE) cases was low, no mortality was observed among these patients at our hospital.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Antibiotic resistance in enterococci is common in children with underlying diseases and HAIs. The early empirical glycopeptide therapy consideration for high\u2010risk patients is supported by the prevalence of ampicillin resistance. These findings underline the importance of continuous local surveillance to guide appropriate empiric antibiotic selection and highlight the need for further research into long\u2010term resistance trends and paediatric\u2010specific treatment strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jpc.70180","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:46:36Z","timestamp":1756363596000},"page":"1763-1772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Paediatric Enterococcal Bacteremia: An Exploration of the Clinical Impact With Emphasis on Antibiotic Resistance"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0023-4758","authenticated-orcid":false,"given":"Ayse","family":"Cakil Guzin","sequence":"first","affiliation":[{"name":"Division of Paediatric Infectious Diseases Faculty of Medicine, Dokuz Eylul University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8784-979X","authenticated-orcid":false,"given":"Irem Ceren","family":"Erbas","sequence":"additional","affiliation":[{"name":"Division of Paediatric Infectious Diseases Faculty of Medicine, Dokuz Eylul University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2662-5039","authenticated-orcid":false,"given":"Silem","family":"Ozdem Alatas","sequence":"additional","affiliation":[{"name":"Division of Paediatric Infectious Diseases Faculty of Medicine, Dokuz Eylul University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4300-3311","authenticated-orcid":false,"given":"Hatice","family":"Karaoglu Asrak","sequence":"additional","affiliation":[{"name":"Division of Paediatric Infectious Diseases Faculty of Medicine, Dokuz Eylul University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3019-0149","authenticated-orcid":false,"given":"Elif","family":"Alacam","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Faculty of Medicine, Dokuz Eyl\u00fcl University  \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4847-987X","authenticated-orcid":false,"given":"Mahmut Cem","family":"Ergon","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Faculty of Medicine, Dokuz Eyl\u00fcl University  \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6488-8641","authenticated-orcid":false,"given":"Eda","family":"Karadag\u2010Oncel","sequence":"additional","affiliation":[{"name":"Division of Paediatric Infectious Diseases Faculty of Medicine, Dokuz Eylul University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1513-1797","authenticated-orcid":false,"given":"Nursen","family":"Belet","sequence":"additional","affiliation":[{"name":"Division of Paediatric Infectious Diseases Faculty of Medicine, Dokuz Eylul University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2023.2223977"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.spid.2006.06.006"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2020.12.005"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000001919"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000003631"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild\u20102018\u2010315387"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469\u20100691.12236"},{"key":"e_1_2_12_9_1","unstructured":"World Health Organization WHO Bacterial Priority Pathogens List 2024: Bacterial Pathogens of Public Health Importance to Guide Research Development and Strategies to Prevent and Control Antimicrobial Resistance https:\/\/www.who.int\/publications\/i\/item\/9789240093461."},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2017.03.009"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871526520999201103191829"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/23744235.2022.2131901"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jacamr\/dlab185"},{"key":"e_1_2_12_14_1","unstructured":"ECDC. 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