{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:53:47Z","timestamp":1791381227779,"version":"4.3.3"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To determine the incidence, causes, and clinical associations of cases of extreme neonatal hyperbilirubinaemia in South Australia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a population\u2010based case\u2013control study of neonates \u2265\u200936\u2009weeks gestation with extreme hyperbilirubinaemia (plasma bilirubin level\u2009\u2265\u2009450\u2009\u03bcmol\/L) in South Australia over a 12\u2010year period, between January 2010 and\u00a0December\u00a02021.\u00a0Cases of extreme hyperbilirubinaemia were detected via a state\u2010wide pathology system. Further details were obtained using medical records. Population data from the SA Health Pregnancy Outcome Unit was used as the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 68 cases were identified. The overall incidence of extreme hyperbilirubinaemia for the 12\u2010year period was\u00a028.6\/100\u2009000 births, higher than a previously published Australian estimate of 9.4\/100\u2009000 live births reported over a similar period and determined by clinician reporting. Extreme hyperbilirubinaemia was associated with Asian ethnicity, ventouse delivery and early discharge. A large peak in 2020 was temporally associated with the onset of the SARS\u2010CoV\u20102 pandemic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The incidence of extreme hyperbilirubinaemia stayed mostly stable over 12\u2009years in South Australia and was higher than previously described via voluntary clinician reporting. Population\u2010based surveillance monitoring via laboratory systems is likely to be more reliable than voluntary clinician reporting. A spike in incidence in 2020 may have occurred due to pandemic\u2010related changes in maternity and neonatal care practices.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jpc.70221","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:10:41Z","timestamp":1761293441000},"page":"1908-1914","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trends in Extreme Neonatal Hyperbilirubinaemia: A Longitudinal Population\u2010Based Case\u2010Control Study"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8558-8146","authenticated-orcid":false,"given":"Beth","family":"Godden","sequence":"first","affiliation":[{"name":"Flinders Medical Centre Neonatal Unit  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Woodman","sequence":"additional","affiliation":[{"name":"College of Medicine and Public Health Flinders University  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Morris","sequence":"additional","affiliation":[{"name":"Flinders Medical Centre Neonatal Unit  Adelaide South Australia Australia"},{"name":"College of Medicine and Public Health Flinders University  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2016-311556"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-022-01204-8"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.08.048"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.105361"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.060328"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.197616"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.0858"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2008.00879.x"},{"issue":"1","key":"e_1_2_13_10_1","first-page":"59","article-title":"Extreme Hyperbilirubinaemia in Term and Near\u2010Term Infants in Denmark","volume":"94","author":"Ebbesen F.","year":"2005","journal-title":"Acta Paediatrica"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2011.02217.x"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.114.1.297"},{"key":"e_1_2_13_13_1","unstructured":"SA Maternal NGCoP Neonatal Jaundice(2010) https:\/\/www.sahealth.sa.gov.au\/wps\/wcm\/connect\/943332804ee50dac985f9dd150ce4f37\/Neonatal+Jaundice+PPG_v2_1.pdf?MOD=AJPERES&CACHEID=ROOTWORKSPACE-943332804ee50dac985f9dd150ce4f37-opXJkXP."},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2010.98"},{"key":"e_1_2_13_15_1","unstructured":"Adelaide: Pregnancy Outcome Unit PaPHB Wellbeing SA Government of South Australia Pregnancy Outcome in South Australia. 2010\u20132021."},{"issue":"5","key":"e_1_2_13_16_1","article-title":"Transcutaneous Bilirubinometry Versus Total Serum Bilirubin Measurement for Newborns","volume":"5","author":"Okwundu C. 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