{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:53:53Z","timestamp":1791381233327,"version":"4.3.3"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate whether an increase in the time to antibiotics (TTA) administration in the paediatric emergency department worsens the clinical outcomes of well\u2010appearing paediatric cancer patients with febrile neutropenia (FN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a subanalysis of a prospective, observational study conducted in two hospitals between November 2019 and October 2021. Multivariate analysis was performed to identify independent risk factors for poor outcomes, defined as admission to the paediatric intensive care unit, sepsis or septic shock, acute organ dysfunction, long\u2010term sequelae, or death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 192 episodes in 163 patients. A total of 110 episodes (57.3%) had a TTA \u2264\u200960\u2009min (short TTA) and 82 (42.7%) had a TTA &gt;\u200960\u2009min (long TTA). Baseline characteristics were similar in both groups, except for previous FN episodes, which were more frequent in the short TTA group (64.5% vs. 8.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Twelve episodes (6.3%) resulted in a poor outcome, although no deaths were reported. Poor outcomes were more common in patients with higher maximum temperature (odds ratio [OR]: 2.7; 95% CI: 1.1\u20136.6), and elevated CRP (OR: 1.01; 95% CI 1.003\u20131.02). In the multivariate analysis, no variable\u2014including TTA\u2014was identified as an independent risk factor for poor outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Delayed antibiotic administration in clinically stable paediatric FN patients did not worsen outcomes, supporting the potential feasibility of a \u2018wait\u2010and\u2010observe focus\u2019 approach.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jpc.70222","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T08:51:53Z","timestamp":1761123113000},"page":"1886-1893","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes in Stable Paediatric Patients With Cancer With Fever and Neutropenia According to Time to Antibiotic Administration: A Prospective Observational Study"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8838-1631","authenticated-orcid":false,"given":"Beatriz","family":"Vergara Mu\u00f1oz","sequence":"first","affiliation":[{"name":"Department of Pediatrics Hospital Infantil Universitario Ni\u00f1o Jes\u00fas  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5792-9386","authenticated-orcid":false,"given":"Monica","family":"Sancosmed Ron","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department Hospital Universitario Vall D'Hebr\u00f3n  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8344-8427","authenticated-orcid":false,"given":"Mar\u00eda","family":"Su\u00e1rez\u2010Bustamante Hu\u00e9lamo","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department Hospital Infantil Universitario Ni\u00f1o Jes\u00fas  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4480-2844","authenticated-orcid":false,"given":"Esther","family":"Lera Carballo","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department Hospital Universitario Vall D'Hebr\u00f3n  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9597-4437","authenticated-orcid":false,"given":"Ana","family":"Rodr\u00edguez Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hospital Infantil Universitario Ni\u00f1o Jes\u00fas  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5664-2593","authenticated-orcid":false,"given":"Rocio","family":"Rodrigo","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department Hospital Universitario Vall D'Hebr\u00f3n  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7648-1336","authenticated-orcid":false,"given":"Jos\u00e9 Antonio","family":"Alonso\u2010Cadenas","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department Hospital Infantil Universitario Ni\u00f1o Jes\u00fas  Madrid Spain"},{"name":"Instituto Investigaci\u00f3n Sanitaria Hospital La Princesa  Madrid 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