{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T20:36:04Z","timestamp":1775680564440,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      To investigate whether postnatal haemoglobin oxygen affinity (P\n                      <jats:sub>50<\/jats:sub>\n                      ), derived from serial arterial blood gases, is associated with the risk of retinopathy of prematurity (ROP) in preterm infants, as a potential physiologic marker.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study included 232 preterm infants born &lt;\u200932\u2009weeks gestation. Haemoglobin P\n                      <jats:sub>50<\/jats:sub>\n                      and lactate values were calculated daily during the first week of life. The primary outcome was the development of any ROP; treatment\u2010requiring (Type 1) ROP was a secondary endpoint. Associations were analysed using logistic regression and ROC analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Infants who developed ROP had significantly higher Day 7 P\n                      <jats:sub>50<\/jats:sub>\n                      values (mean 26.9\u2009\u00b1\u20091.8\u2009mmHg) than those without ROP (26.1\u2009\u00b1\u20091.7\u2009mmHg;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). A Day 7 P\n                      <jats:sub>50<\/jats:sub>\n                      &gt;\u200926.4\u2009mmHg was independently associated with ROP (OR 2.5; 95% CI 1.3\u20134.9), though predictive performance was modest (AUC 0.60). Lactate levels showed no association with ROP. P\n                      <jats:sub>50<\/jats:sub>\n                      was not predictive of Type 1 ROP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Increased postnatal P\n                      <jats:sub>50<\/jats:sub>\n                      may be modestly associated with ROP development, reflecting impaired oxygen delivery during early retinal vascularization. While not suitable for screening, P\n                      <jats:sub>50<\/jats:sub>\n                      may serve as a physiologic marker warranting further mechanistic investigation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jpc.70231","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T11:06:37Z","timestamp":1762945597000},"page":"61-65","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Early Haemoglobin Oxygen Affinity as a Hypothesis\u2010Generating Marker for Retinopathy of Prematurity Risk in Preterm Infants"],"prefix":"10.1111","volume":"62","author":[{"given":"Yakup","family":"Karakurt","sequence":"first","affiliation":[{"name":"Department of Neonatology Ba\u011fc\u0131lar Training and Research Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2163-6564","authenticated-orcid":false,"given":"Emrah","family":"Can","sequence":"additional","affiliation":[{"name":"Department of Neonatology University of Health Sciences  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.07.050"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(13)60178\u20106"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211447"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.04.034"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198707023170104"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450\u2010197103000\u201000007"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390\u2010024\u201003646\u2010x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.02.004"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000014142"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2025.111707"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(95)92466\u20104"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431\u2010020\u201003765\u20101"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa023080"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.84.2.f106"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.2.339"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.70231","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jpc.70231","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.70231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T08:28:21Z","timestamp":1768379301000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.70231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,12]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/jpc.70231"],"URL":"https:\/\/doi.org\/10.1111\/jpc.70231","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"value":"1034-4810","type":"print"},{"value":"1440-1754","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,12]]},"assertion":[{"value":"2025-08-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}