{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T20:50:03Z","timestamp":1773262203398,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1197335"],"award-info":[{"award-number":["1197335"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Sepsis is a major cause of mortality among children, with the highest burden evident in neonates and young infants, particularly, in resource\u2010constrained healthcare settings. Despite this burden, there are insufficient published data to delineate the epidemiology of neonatal sepsis from many of these settings. We aimed to address this research gap by evaluating the epidemiology of sepsis in neonates and young infants in Sri Lanka, a populous country in Southeast Asia, and to evaluate the efficacy of currently\u2010recommended empiric antibiotic regimens to treat these infections in the context of evolving antimicrobial resistance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>We evaluated the pathogens (including susceptibility profiles) responsible for infections in neonates and young infants over a 7\u2010year period alongside clinical outcomes (2015\u20132021).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>A 1100 bed urban tertiary hospital in Colombo, Sri Lanka.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>Neonates and young infants (aged 0 to \u2264\u2009180\u2009days).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Blood culture\u2010positive pathogen profiles, antibiotic susceptibility against empiric antibiotic regimens and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 231 neonates and young infants with clinically significant blood cultures incorporating 251 pathogens over the study period, of whom 22 died. Where gestational data were available, most babies with culture\u2010positive sepsis were premature (71%, 65\/91), born at a median gestational age of 32\u2009weeks (interquartile range [IQR] 27\u201338\u2009weeks). Gram\u2010negative bacteria predominated as a cause of culture\u2010positive infections (66%, 166\/251), including in 86% of neonates and young infants who died (19\/22). There were high rates of non\u2010susceptibility to first\u2010 and second\u2010line antibiotics currently recommended to treat neonatal sepsis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There is a high burden of antibiotic\u2010resistant gram\u2010negative infections in neonates and young infants in Sri Lanka, highlighting an urgent need to prioritise the development of new antimicrobial regimens to treat neonatal infections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jpc.70269","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T10:48:25Z","timestamp":1769078905000},"page":"446-455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antimicrobial Resistance and Infant Mortality in Sri Lanka: A Retrospective Cohort Study"],"prefix":"10.1111","volume":"62","author":[{"given":"Gayana P. S.","family":"Gunaratna","sequence":"first","affiliation":[{"name":"Colombo South Teaching Hospital  Colombo Sri Lanka"},{"name":"Department of Medical Microbiology Faculty of Medicine, University of Kelaniya  Colombo Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4608-2659","authenticated-orcid":false,"given":"Michelle L.","family":"Harrison","sequence":"additional","affiliation":[{"name":"School of Public Health Faculty of Medicine &amp; Health, The University of Sydney  Sydney Australia"},{"name":"Sydney Institute for Infectious Diseases (Sydney ID), The University of Sydney  Camperdown Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin F. R.","family":"Dickson","sequence":"additional","affiliation":[{"name":"School of Public Health Faculty of Medicine &amp; Health, The University of Sydney  Sydney Australia"},{"name":"Sydney Institute for Infectious Diseases (Sydney ID), The University of Sydney  Camperdown Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajeev","family":"Sathanandaraja","sequence":"additional","affiliation":[{"name":"Colombo South Teaching Hospital  Colombo Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. M. Ruwanthi","family":"Perera","sequence":"additional","affiliation":[{"name":"Colombo South Teaching Hospital  Colombo Sri Lanka"},{"name":"Department of Paediatrics Faculty of Medical Sciences, University of Sri Jayewardenepura  Gangodawila Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nambage Shirani","family":"Chandrasiri","sequence":"additional","affiliation":[{"name":"Colombo South Teaching Hospital  Colombo Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anasuya","family":"Sutharson","sequence":"additional","affiliation":[{"name":"Colombo South Teaching Hospital  Colombo Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jannah","family":"Baker","sequence":"additional","affiliation":[{"name":"School of Public Health Faculty of Medicine &amp; Health, The University of Sydney  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2250-0594","authenticated-orcid":false,"given":"Phoebe C. 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