{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:14:49Z","timestamp":1787015689999,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2026,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Aim<\/jats:title>\n To evaluate clinical features, management, and outcomes of paediatric bone and joint infection (BJI) in a regional Australian hospital and assess weight\u2010based oral antibiotic prescribing.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We conducted a retrospective study of 171 children aged 0\u201318\u2009years admitted with septic arthritis and\/or osteomyelitis between 2011 and 2021. Cases were identified using ICD\u201010\u2010AM codes, and data on clinical presentation, microbiology and treatment were extracted from medical records. Oral antibiotic doses were assessed against international evidence\u2010based guidelines.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 171 children were included (median age 27\u2009months); 59.6% were aged \u2264\u20095\u2009years, and 13.5% identified as Aboriginal or Torres Strait Islander.\n \n Staphylococcus aureus<\/jats:italic>\n <\/jats:styled-content>\n was the most frequently identified pathogen overall (53\/108, 49.1%), and\n \n Kingella kingae<\/jats:italic>\n <\/jats:styled-content>\n in children <\u20095\u2009years of age (20\/57, 35.1%). Severe disease occurred in 29.8%. Oral antibiotic doses were below international guideline recommendations in 43.3% of cases, mostly with amoxicillin\u2013clavulanate and cephalexin. Relapse (4.1%) and long\u2010term sequelae (6.1%) were infrequent.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Paediatric BJI mostly occurred in young and in Aboriginal and Torres Strait Islander children. Oral antibiotic weight\u2010based dosing was often lower than international guideline recommendations for BJI. These findings highlight the need for standardised antibiotic dosing in BJI and further studies to optimise dosing in children.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jpc.70293","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T04:35:48Z","timestamp":1769142948000},"page":"456-462","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Management and Outcomes of Paediatric Bone and Joint Infections in a Regional Australian Hospital: A 10\u2010Year Retrospective Study"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2146-3253","authenticated-orcid":false,"given":"Niall","family":"Johnston","sequence":"first","affiliation":[{"name":"Department of General Paediatric and Adolescent Medicine John Hunter Children's Hospital New Lambton Heights New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rani","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Department of Paediatric Allergy and Immunology John Hunter Children's Hospital New Lambton Heights New South Wales Australia"},{"name":"School of Medicine and Public Health University of Newcastle Newcastle New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coen","family":"Butters","sequence":"additional","affiliation":[{"name":"Department of General Paediatric and Adolescent Medicine John Hunter Children's Hospital New Lambton Heights New South Wales Australia"},{"name":"Murdoch Children's Research Institute Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.16711"},{"issue":"7","key":"e_1_2_11_3_1","first-page":"815","article-title":"Consensus Guidelines on the Management of Musculoskeletal Infection Affecting Children in the UK","volume":"105","author":"Mitchell P. D.","year":"2023","journal-title":"Bone & Joint Journal"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piab027"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piad089"},{"key":"e_1_2_11_6_1","first-page":"1","article-title":"ESPID Bone and Joint Guideline","volume":"44","author":"Saavedra J.","year":"2017","journal-title":"Bone & Joint Infection"},{"key":"e_1_2_11_7_1","unstructured":"The Royal Children's Hospital Melbourne \u201cClinical Practice Guidelines Bone and Joint Infection \u201dJune 29 2025 https:\/\/www.rch.org.au\/clinicalguide\/guideline_index\/Osteomyelitis_Septic_Arthritis\/."},{"key":"e_1_2_11_8_1","unstructured":"Your Council New South Wales \u201cAustralian Classification of Local Government and OLG Group Numbers \u201dAugust 21 2023 https:\/\/www.yourcouncil.nsw.gov.au\/."},{"key":"e_1_2_11_9_1","unstructured":"Australian Medicines Handbook Pty Ltd \u201cAMH Children's Dosing Companion \u201dJune 29 2025 https:\/\/childrens.amh.net.au\/auth."},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002885"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/BPO.0000000000001187"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.L.00037"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/hpeds.2022-006822"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjoq-2020-001120"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30024-X"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-022-01934-4"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002646"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.70293","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jpc.70293","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.70293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T04:36:30Z","timestamp":1773203790000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.70293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,22]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/jpc.70293"],"URL":"https:\/\/doi.org\/10.1111\/jpc.70293","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"value":"1034-4810","type":"print"},{"value":"1440-1754","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,22]]},"assertion":[{"value":"2024-06-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}