{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T04:57:18Z","timestamp":1781153838199,"version":"3.54.1"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Early prediction of necrotising enterocolitis (NEC) in preterm infants is important given its significant health, economic and social\u2013emotional burden. We aimed to validate a clinical risk score (Check\u2010NEC Score [CNS]) for this purpose in preterm infants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A case\u2013control study was conducted using data (January 2020\u2013December 2023) from very preterm infants (VP: gestation\u2009&lt;\u200932\u2009weeks) with confirmed NEC\u2265Stage II. CNS was calculated for cases and controls (matched for key confounders) at baseline (T1), 7\u2009days (T2), and 72\u2009h (T3) before NEC diagnosis. Receiver operating characteristic (ROC) analysis was used to determine the sensitivity, specificity, and area under the curve (AUC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010two cases of NEC\u2265Stage II diagnosed at a median (IQR) age of 17 (11\u201324) days were matched with 22 controls. Median CNS was significantly higher in cases compared to controls at T2 (8 vs. 7,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025) and T3 (8 vs. 7,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005). T3 CNS had the highest AUC (0.64, 95% CI 0.48\u20130.81). A cut\u2010off score of \u2265\u200911 at T2 had the highest specificity (95%, 95% CI 75%\u201399%). At T3, a cut\u2010off score of either \u2265\u20098 or \u2265\u20099 was best.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CNS demonstrated acceptable predictive ability at 72\u2009h with high specificity 7\u2009days before NEC diagnosis, depending on the cut\u2010off score chosen.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jpc.70364","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T04:01:28Z","timestamp":1773720088000},"page":"944-952","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of a Clinical Risk Score for Preterm Necrotising Enterocolitis: The \u2018Check\u2010\n                    <scp>NEC<\/scp>\n                    Score\u2019"],"prefix":"10.1111","volume":"62","author":[{"given":"Tiara","family":"Davis","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences, University of Western Australia  Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandra","family":"Rath","sequence":"additional","affiliation":[{"name":"Department of Neonatology Child and Adolescent Health Service, King Edward Memorial Hospital  Perth Western Australia Australia"},{"name":"School of Medicine, University of Western Australia  Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4732-6043","authenticated-orcid":false,"given":"Gayatri","family":"Athalye\u2010Jape","sequence":"additional","affiliation":[{"name":"Department of Neonatology Child and Adolescent Health Service, King Edward Memorial Hospital  Perth Western Australia Australia"},{"name":"School of Medicine, University of Western Australia  Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Nathan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Western Australia  Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Keelan","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, University of Western Australia  Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Patole","sequence":"additional","affiliation":[{"name":"Department of Neonatology Child and Adolescent Health Service, King Edward Memorial Hospital  Perth Western Australia Australia"},{"name":"School of Medicine, University of Western Australia  Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2019.11.011"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.049189"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1188\/13.CJON.21\u201024"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semperi.2022.151694"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.2142"},{"issue":"6","key":"e_1_2_13_7_1","first-page":"B5362","article-title":"Necrotizing Enterocolitis \u2010 Classification and Two Initial Steps Towards Prevention","volume":"64","author":"Juhl S. 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