{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:07:10Z","timestamp":1784297230859,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This is the study protocol of an ongoing prospective randomised controlled trial (RCT) designed to assess the safety and efficacy of early enteral nutrition after elective enterostomy closure in children, written in accordance with the SPIRIT guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This is a multicentre, RCT that will be conducted in two Australian tertiary paediatric hospitals with a planned sample size of 68. Children that meet the inclusion criteria aged between 3 months and 16\u2009years (inclusive) undergoing an elective enterostomy closure will be invited to participate. To assign treatment group, stratified permutated block randomisation will be used, with block sizes of four and six, and strata including: age group (3\u2009months\u2013&lt;\u20096\u2009years, 6\u2013\u2264\u200916\u2009years); stoma type (ileostomy, colostomy); and hospital (Sydney Children's Hospital, Randwick, The Children's Hospital at Westmead). The control group will commence feeds on return of bowel function or when nasogastric tube aspirates are non\u2010bilious. The intervention group will be offered feeds within 24\u2009h of admission to the recovery room. The primary outcome is the length of stay, measured in hours. Secondary outcomes include time to oral feeds, time to first spontaneous passage of stool, highest post\u2010operative pain score, complications, analgesia use and parent satisfaction. Data analyses will use an intention\u2010to\u2010treat principle. Length of stay, time to feeds and passing of stool will be analysed using restricted mean survival time. Other secondary outcomes will be analysed using regression models.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jpc.70368","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T04:25:30Z","timestamp":1776831930000},"page":"1141-1148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Enteral Nutrition After Paediatric Ostomy Closure (\n                    <scp>EPOC<\/scp>\n                    ): A Protocol for a Multicentre, Prospective Randomised Controlled Trial"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9474-2487","authenticated-orcid":false,"given":"Joyce","family":"Ly","sequence":"first","affiliation":[{"name":"Discipline of Paediatrics and Child Health, School of Clinical Medicine The University of New South Wales  Kensington New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9243-6933","authenticated-orcid":false,"given":"James","family":"Cope","sequence":"additional","affiliation":[{"name":"Discipline of Paediatrics and Child Health, School of Clinical Medicine The University of New South Wales  Kensington New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Olsen","sequence":"additional","affiliation":[{"name":"Stats Central, Mark Wainwright Analytical Centre The University of New South Wales  Kensington New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soundappan S. V.","family":"Soundappan","sequence":"additional","affiliation":[{"name":"Sydney Medical School The University of Sydney  Sydney New South Wales Australia"},{"name":"Douglas Cohen Department Paediatric Surgery The Children's Hospital at Westmead  Westmead New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Adams","sequence":"additional","affiliation":[{"name":"Discipline of Paediatrics and Child Health, School of Clinical Medicine The University of New South Wales  Kensington New South Wales Australia"},{"name":"Injury Division The George Institute for Global Health  Newtown New South Wales Australia"},{"name":"Toby Bowring Department Paediatric Surgery Sydney Children's Hospital  Randwick New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2021.07.020"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0189-6725.115025"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2004.10.003"},{"issue":"9","key":"e_1_2_13_5_1","article-title":"The Impact of Early Enteral Nutrition on Pediatric Patients Undergoing Gastrointestinal Anastomosis a Propensity Score Matching Analysis","volume":"97","author":"Shang Q.","year":"2018","journal-title":"Medicine (United States)"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2016.02.004"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2013.02.013"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2015.11.018"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533609335176"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/78.5.606"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004080.pub4"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.323.7316.773"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02237227"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2010.01.004"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(88)80192-2"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607180004006535"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.4236\/ss.2013.41008"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/jiaps.JIAPS_132_19"},{"issue":"2","key":"e_1_2_13_19_1","first-page":"59","article-title":"Early Versus Delayed Feeding in Pediatric Patients Following Stoma Reversal in a Resource Limited Environment","volume":"6","author":"Iqbal M. 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