{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T04:57:38Z","timestamp":1781153858296,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006002","name":"Zonguldak B\u00fclent Ecevit \u00dcniversitesi","doi-asserted-by":"publisher","award":["2024\u201098790617\u201001"],"award-info":[{"award-number":["2024\u201098790617\u201001"]}],"id":[{"id":"10.13039\/501100006002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Although short\u2010term cardiometabolic complications are not usually expected in children with metabolically healthy obesity (MHO), subclinical vascular damage may still occur. This study aimed to evaluate Fibroblast Growth Factor 21 (FGF21) levels in children with obesity and their relationship with carotid intima\u2010media thickness (CIMT) and other cardiometabolic risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Children with obesity were defined based on their metabolic health status. Children meeting all of the following criteria were categorised as MHO: High\u2010density lipoprotein (HDL) &gt;\u20091.03\u2009mmol\/L, triglycerides (TG)\u2009\u2264\u20091.7\u2009mmol\/L, systolic and diastolic blood pressure\u2009\u2264\u200990th percentile for age and height, and fasting glucose &lt;\u20095.6\u2009mmol\/L. Children who did not meet one or more criteria were defined as having metabolically unhealthy obesity (MUO). Anthropometric measurements, serum FGF21 levels, biochemical tests and CIMT assessments were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study was conducted between March and September 2024 with 64 obese and 32 healthy children aged 7\u201318\u2009years. Children with MUO had the highest mean FGF21 levels. CIMT values were significantly higher in children with MUO compared with children with MHO and healthy controls, whilst no difference was observed between children with MHO and healthy controls. No significant correlation was found between FGF21 and CIMT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>FGF21 levels were elevated in children with MUO compared with children with MHO and healthy controls. However, FGF21 does not appear to be a reliable biomarker. Further studies are required to clarify this relationship.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jpc.70375","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T04:55:39Z","timestamp":1774587339000},"page":"967-973","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fibroblast Growth Factor 21 and Cardiometabolic Risk Markers in Metabolically Healthy and Unhealthy Obese Children"],"prefix":"10.1111","volume":"62","author":[{"given":"Can","family":"Kur\u015fun","sequence":"first","affiliation":[{"name":"Department of Pediatrics Nev\u015fehir State Hospital  Nev\u015fehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9252-1652","authenticated-orcid":false,"given":"Z\u00fchal","family":"\u00d6rnek","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Zonguldak B\u00fclent Ecevit University  Zonguldak Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berrak","family":"G\u00fcven","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine Zonguldak B\u00fclent Ecevit University  Zonguldak Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banu","family":"Al\u0131c\u0131o\u011flu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine Zonguldak B\u00fclent Ecevit University  Zonguldak Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-1706"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12721"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.21931\/RB\/2023.08.03.75"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1476"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007\u20102329C"},{"issue":"1","key":"e_1_2_11_7_1","first-page":"241","article-title":"Carotid Intima Media\u2010Thickness Is Increased in Obese Children Metabolically Healthy, Metabolically Unhealthy, and With Metabolic Syndrome, Compared to the Non\u2010Obese Controls","volume":"25","author":"Farello G.","year":"2021","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13121680"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.4526"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-1904"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1457598"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2007.11.011"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.73936"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.6065\/apem.2040258.129"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.15.1609"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872\u2010018\u20100874\u20105"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1515\/hmbci-2016-0026"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.015226"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.301599"},{"issue":"3","key":"e_1_2_11_20_1","first-page":"248","article-title":"Atherogenic Index of Plasma as Useful Predictor of Cardiovascular Risk Among Postmenopausal Women in Enugu, Nigeria","volume":"10","author":"Nwagha U. 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