{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T04:57:25Z","timestamp":1781153845658,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Rationale<\/jats:title>\n Cystic fibrosis (CF) is characterised by chronic inflammation and malnutrition, significantly affecting disease progression and prognosis. The haemoglobin\u2010albumin\u2010lymphocyte\u2010platelet (HALP) score reflects inflammatory and nutritional status, and has prognostic associations in various chronic diseases; its role in paediatric CF is unclear.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n To evaluate the association between HALP measured during clinical stability and (i) baseline disease severity at the index assessment (FEV\n 1<\/jats:sub>\n , MSKS, and BMI z\u2010score), and (ii) subsequent 12\u2010month outcomes (hospitalisation\u2010requiring pulmonary exacerbations, PICU admission, and mortality) in children with CF.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Retrospective single\u2010centre cohort study of 152 children with CF aged 2\u201318\u2009years. HALP was calculated at clinical stability. Associations with index severity and 12\u2010month outcomes were analysed; logistic regression for low FEV\n 1<\/jats:sub>\n was restricted to participants with acceptable spirometry.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Lower HALP was associated with low FEV\n 1<\/jats:sub>\n (<\u200970% predicted) at the index assessment (\n p<\/jats:italic>\n \u2009<\u20090.001) and with a higher 12\u2010month burden of hospitalisation \u2010requiring pulmonary exacerbations (\n p<\/jats:italic>\n \u2009<\u20090.001). PICU admission and mortality were infrequent and analysed exploratorily; HALP was lower in these groups (PICU\n p<\/jats:italic>\n \u2009<\u20090.001; mortality\n p<\/jats:italic>\n \u2009=\u20090.004). In adjusted logistic regression among participants with spirometry (\n n<\/jats:italic>\n \u2009=\u2009101), HALP remained associated with low FEV\n 1<\/jats:sub>\n , although the effect size was modest and precision limited (adjusted OR 0.886, 95% CI 0.788\u20130.996;\n p<\/jats:italic>\n \u2009=\u20090.043).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n HALP, reflecting nutritional and inflammatory status, may offer prognostic information in paediatric\u00a0CF.\u00a0Calculation from routine blood tests could make it a practical tool for identifying higher\u2010risk individuals and informing\u00a0clinical decision\u2010making. Further large\u2010scale studies are needed to validate its clinical utility in CF management.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jpc.70382","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T04:15:30Z","timestamp":1775189730000},"page":"989-997","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Can the\n HALP<\/scp>\n Score Be Used as a Prognostic Marker in Paediatric Patients With Cystic Fibrosis?"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7828-7504","authenticated-orcid":false,"given":"K\u00fcbra","family":"\u00d6zkaya","sequence":"first","affiliation":[{"name":"Department of Pediatric Pulmonology Ege University Faculty of Medicine Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0793-9710","authenticated-orcid":false,"given":"G\u00f6k\u00e7en Kartal","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology Ege University Faculty of Medicine Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0523-4856","authenticated-orcid":false,"given":"Bahar Girgin","family":"Dindar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology Ege University Faculty of Medicine Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4859-2933","authenticated-orcid":false,"given":"Ece","family":"Halis","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology Ege University Faculty of Medicine Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1992-1603","authenticated-orcid":false,"given":"Fevziye","family":"\u00c7oks\u00fcer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology Ege University Faculty of Medicine Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6195-5474","authenticated-orcid":false,"given":"Atacan","family":"\u00d6\u011f\u00fctc\u00fc","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology Ege University Faculty of Medicine Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3725-4851","authenticated-orcid":false,"given":"Hazal","family":"Gacemer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology Ege University Faculty of Medicine Izmir 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