{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T05:13:02Z","timestamp":1777957982318,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Community\u2010acquired pneumonia (CAP) remains a major cause of morbidity in children. Although severity assessment tools are available, they are not specifically designed to predict the development of a broad spectrum of pulmonary and systemic complications. This study aimed to identify admission factors associated with complicated pneumonia (CP) in hospitalized children with CAP and to develop a practical risk scoring model for early risk stratification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients hospitalized with CAP were classified into two categories: uncomplicated CAP and complicated pneumonia. Independent predictors for the development of complicated pneumonia were identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Multivariate logistic regression identified the following as independent risk factors for complicated pneumonia: older age (OR: 1.011;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), hypotension (OR: 28.083;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), altered mental status (OR: 5.033;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.024), low haemoglobin values (OR: 0.835;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015), leukopenia (OR: 3.197;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.040), increased neutrophil\u2010to\u2010lymphocyte ratio levels (OR: 1.045;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.049), hyponatremia (OR: 2.840;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), hypoalbuminemia (OR: 6.489;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and increased C\u2010reactive protein levels (OR: 1.034;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039). The scoring system demonstrated a sensitivity of 82% and a specificity of 79%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We identified admission characteristics associated with the development of pulmonary and systemic complications in hospitalized children with CAP and developed a complication\u2010focused risk scoring model based on routinely available parameters. The model showed good performance within this retrospective cohort and may support early risk stratification. Prospective multicentre validation is required to confirm its generalizability and clinical utility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jpc.70407","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T04:35:09Z","timestamp":1777955709000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk Stratification for Complications in Patients Hospitalized With Community\u2010Acquired Pneumonia"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9676-2022","authenticated-orcid":false,"given":"I\u015f\u0131n Senem K\u00f6\u015fker","family":"\u00c7apar","sequence":"first","affiliation":[{"name":"Department of Pediatrics Akdeniz University Hospital  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0716-7607","authenticated-orcid":false,"given":"Tu\u011f\u00e7e","family":"Tural\u2010Kara","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Disease Akdeniz University Hospital  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization \u201cPneumonia in Children \u201dhttps:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/pneumonia."},{"issue":"7","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/cid\/cir531","article-title":"Pediatric Infectious Diseases Society and the Infectious Diseases Society of America. The Management of Community\u2010Acquired Pneumonia in Infants and Children Older Than 3 Months of Age: Clinical Practice Guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America","volume":"53","author":"Bradley J. S.","year":"2011","journal-title":"Clinical Infectious Diseases"},{"issue":"10253","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/S0140-6736(20)31550-6","article-title":"Complicated Pneumonia in Children","volume":"396","author":"Benedictis F. 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Y.","year":"2015","journal-title":"Journal of Microbiology, Immunology, and Infection"},{"issue":"1","key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/crj.12524","article-title":"Risk Factors for Local Complications in Children With Community\u2010Acquired Pneumonia","volume":"12","author":"Krenke K.","year":"2018","journal-title":"Clinical Respiratory Journal"},{"key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jpeds.2016.05.025","article-title":"Children, Antibiotics, Nonsteroidal Anti\u2010Inflammatory Drugs and Childhood Empyema (ChANCE) Study Group. 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