{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T22:41:02Z","timestamp":1789339262850,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:00:00Z","timestamp":1777680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:00:00Z","timestamp":1777680000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Early recognition and treatment of paediatric sepsis has been shown to improve survival. Automated sepsis alerts embedded in electronic medical records (\n                    <jats:styled-content style=\"fixed-case\">EMRs<\/jats:styled-content>\n                    ) offer real\u2010time identification of high\u2010risk patients and may improve timeliness of sepsis care, with possible limitations including overdiagnosis, overtreatment and alert fatigue. It is currently unclear whether automated alerts improve clinical outcomes in paediatric sepsis. We conducted a systematic review and narrative synthesis of studies evaluating clinical outcomes (mortality,\n                    <jats:styled-content style=\"fixed-case\">PICU<\/jats:styled-content>\n                    admission rate, length of stay), process measures (time to fluids\/antibiotics, bundle adherence), and balancing measures (hospitalisation rate, antibiotic use) after implementation of\n                    <jats:styled-content style=\"fixed-case\">EMR<\/jats:styled-content>\n                    \u2010based automated sepsis alerts in patients under 18\u2009years of age. Twelve studies met inclusion criteria. Automated alerts were associated with improvements in process measures, notably reduced time to antibiotics (4\/6 studies) and fluids (2\/5 studies). Mortality was reduced in one study of\n                    <jats:styled-content style=\"fixed-case\">PICU<\/jats:styled-content>\n                    patients (29.9% vs. 17.4%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.011), and a trend towards reduced\n                    <jats:styled-content style=\"fixed-case\">PICU<\/jats:styled-content>\n                    admissions was observed. No significant impact on hospital or\n                    <jats:styled-content style=\"fixed-case\">PICU<\/jats:styled-content>\n                    length of stay was noted. Alerts did not increase hospital admission rates or antibiotic usage. Automated sepsis alerts may improve time to fluids and antibiotics in paediatric sepsis. While inconsistently reported, alerts were not found to increase hospital admission rates or antibiotic use. The impact on clinical outcomes, particularly mortality, remains uncertain. High quality randomised studies are needed to define their role in improving paediatric sepsis outcomes.\n                  <\/jats:p>","DOI":"10.1111\/jpc.70412","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:10:01Z","timestamp":1777705801000},"page":"1314-1326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Alerts and Alarms\u2014Can Electronic Medical Records Help Children and Adolescents Survive Sepsis?"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4820-557X","authenticated-orcid":false,"given":"Ben","family":"Driver","sequence":"first","affiliation":[{"name":"Murdoch Children's Research Institute  Parkville Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1107-2187","authenticated-orcid":false,"given":"Franz E.","family":"Babl","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute  Parkville Australia"},{"name":"Department of Paediatrics The University of Melbourne  Parkville Australia"},{"name":"Emergency Department Royal Children's Hospital  Parkville Australia"},{"name":"Department of Critical Care The University of Melbourne  Parkville Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5455-957X","authenticated-orcid":false,"given":"Daryl","family":"Cheng","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute  Parkville Australia"},{"name":"Department of Paediatrics The University of Melbourne  Parkville Australia"},{"name":"Centre for Health Analytics, Melbourne Children's Campus  Parkville Australia"},{"name":"Department of General Medicine Royal Children's Hospital  Parkville 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Infectious Diseases Royal Children's Hospital  Parkville Australia"},{"name":"Pharmacy Department Royal Children's Hospital  Parkville Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Williams","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute  Parkville Australia"},{"name":"Emergency Department Royal Children's Hospital  Parkville Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0371-8176","authenticated-orcid":false,"given":"Gabrielle M.","family":"Haeusler","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute  Parkville Australia"},{"name":"Department of Paediatrics The University of Melbourne  Parkville Australia"},{"name":"Department of Infectious Diseases Royal Children's Hospital  Parkville Australia"},{"name":"National Centre for Infections in Cancer, Sir Peter MacCallum Department of Oncology The University of 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