{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:36:34Z","timestamp":1786988194865,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Kaposiform haemangioendothelioma is a rare vascular tumour. Management has evolved over the last two decades, with most cases receiving vincristine or sirolimus. We aim to describe our experience with managing this tumour, with a focus on the safety and efficacy of vincristine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study of all cases treated at Sydney Children's Hospital over a 19\u2010year period was conducted. Explanatory variables included age, tumour location, imaging, the presence of Kasabach\u2010Merrit Phenomenon, and treatment modality. The primary outcome was disease recurrence and the secondary outcome, complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010one cases were identified with 13 (60%) presenting as neonates. The most common site was limb; and imaging included ultrasound (7\/21, 33%) and MRI (12\/21, 57%). Almost all had consumptive coagulopathy (20\/21, 95%) with 6\/21 (29%) having severe Kasabach\u2010Merrit Phenomenon. Six tumours were excised and 16 (76%) were treated with vincristine, with three (14%) progressing to treatment with sirolimus. There were no recurrences. Complications of vincristine therapy were common but mild in most cases, with only one proven blood stream infection and one requiring central line replacement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vincristine remains a highly effective first\u2010line treatment for kaposiform haemangioendothelioma with an acceptable safety profile. Further well\u2010designed multicentre trials are needed to objectively compare its effectiveness and safety with sirolimus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jpc.70461","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T12:08:37Z","timestamp":1780661317000},"page":"1450-1457","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Management of Kaposiform Haemangioendothelioma\u2014A Retrospective Case Series Examining the Use and Effectiveness of Vincristine"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1701-636X","authenticated-orcid":false,"given":"Bronwen","family":"Kirk","sequence":"first","affiliation":[{"name":"John Hunter Children's Hospital  New Lambton Heights New South Wales Australia"},{"name":"School of Medicine and Public Health University of Newcastle  Callaghan New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5629-8414","authenticated-orcid":false,"given":"Susan","family":"Adams","sequence":"additional","affiliation":[{"name":"Vascular Tumours and Anomalies Clinic, Minderoo Kids Cancer Centre Sydney Children's Hospital  Randwick New South Wales Australia"},{"name":"Women's Health, Paediatrics and Child Health, School of Clinical Medicine University of New South Wales  Kensington New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4466-6985","authenticated-orcid":false,"given":"Orli","family":"Wargon","sequence":"additional","affiliation":[{"name":"Vascular Tumours and Anomalies Clinic, Minderoo Kids Cancer Centre Sydney Children's Hospital  Randwick New South Wales Australia"},{"name":"Women's Health, Paediatrics and Child Health, School of Clinical Medicine University of New South Wales  Kensington New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6011-9757","authenticated-orcid":false,"given":"Artiene","family":"Tatian","sequence":"additional","affiliation":[{"name":"Vascular Tumours and Anomalies Clinic, Minderoo Kids Cancer Centre Sydney Children's Hospital  Randwick New South Wales Australia"},{"name":"Women's Health, Paediatrics and Child Health, School of Clinical Medicine University of New South Wales  Kensington New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Russell","sequence":"additional","affiliation":[{"name":"Vascular Tumours and Anomalies Clinic, Minderoo Kids Cancer Centre Sydney Children's Hospital  Randwick New South Wales Australia"},{"name":"Women's Health, Paediatrics and Child Health, School of Clinical Medicine University of New South Wales  Kensington New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.06.044"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.35344"},{"issue":"3","key":"e_1_2_12_4_1","first-page":"E17","article-title":"Kaposiform Hemangioendothelioma With Kasabach\u2010Merritt Syndrome Mistaken for Child Abuse in a Newborn","volume":"93","author":"Cyrulnik A. 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