{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T04:57:09Z","timestamp":1790571429025,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Stimulant medications dexamphetamine and methylphenidate are well\u2010established for the treatment of Attention Deficit Hyperactivity Disorder (ADHD), but few studies directly compare their efficacy. We aimed to compare the therapeutic and adverse effects of immediate\u2010release formulations of dexamphetamine and methylphenidate during the initial treatment of children with ADHD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This open\u2010label study was conducted in public and private specialist paediatric clinics in New South Wales, Australia, between 2016 and 2020. One hundred stimulant\u2010na\u00efve children and adolescents with DSM\u20105\u2010confirmed ADHD were randomised 1:1 to dexamphetamine or methylphenidate. ADHD diagnosis was based on detailed clinical assessment supported by parent and teacher DSM\u20105\u2010based ratings. Dose titration followed a standardised 4\u2010week weight\u2010based protocol monitored with weekly school\u2010based IOWA Conners ratings, after which dose adjustment or switching was made as clinically indicated. Participants were followed for 12\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Study participants (mean age 9.08 [SD 2.87] years; range 4.5\u201316.4\u2009years; 73% male) showed significant ADHD symptom improvement on either medication at all time periods (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), with no significant between\u2010group difference on repeated\u2010measures ANOVA. At 12\u2009months, 62 participants remained on their allocated medication, with no apparent preference between methylphenidate and dexamphetamine (34\/50 [68%] vs. 28\/50 [56%],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.15). Both medications were associated with weight loss which was greater on dexamphetamine at 3\u2009months (\u22121.44 [SD 2.42] kg vs. \u22120.31 [SD 0.97] kg;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Stimulant medications dexamphetamine and methylphenidate appear comparable in short\u2010term symptom response and 12\u2010month persistence after initial randomised allocation, but dexamphetamine may be associated with greater weight loss.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      Australian New Zealand Clinical Trials Registry number: ACTRN12616000569404\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jpc.70487","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:18:29Z","timestamp":1783487909000},"page":"1621-1629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Randomised Open\u2010Label Comparison of Dexamphetamine and Methylphenidate in Children With Attention Deficit Hyperactivity Disorder (\n                    <scp>ADHD<\/scp>\n                    ): Symptom Response, Adherence and Weight Impact Over 12\u2009Months"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5867-2403","authenticated-orcid":false,"given":"Alison","family":"Poulton","sequence":"first","affiliation":[{"name":"Nepean Clinical School, Faculty of Medicine and Health, The University of Sydney  Kingswood New South Wales Australia"},{"name":"Department of Paediatrics Nepean Hospital, Nepean Blue Mountains Local Health District  Kingswood New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Nepean Hospital, Nepean Blue Mountains Local Health District  Kingswood New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoang Cuc","family":"Do","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Nepean Hospital, Nepean Blue Mountains Local Health District  Kingswood New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Chau","sequence":"additional","affiliation":[{"name":"Recess Psychology  Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Simons","sequence":"additional","affiliation":[{"name":"Nepean Clinical School, Faculty of Medicine and Health, The University of Sydney  Kingswood New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Nepean Clinical School, Faculty of Medicine and Health, The University of Sydney  Kingswood New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Nepean Clinical School, Faculty of Medicine and Health, The University of Sydney  Kingswood New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Ng","sequence":"additional","affiliation":[{"name":"Nepean Clinical School, Faculty of Medicine and Health, The University of Sydney  Kingswood New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Dyson","sequence":"additional","affiliation":[{"name":"Nepean Clinical School, Faculty of Medicine and Health, The University of Sydney  Kingswood New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5114-9380","authenticated-orcid":false,"given":"Habib","family":"Bhurawala","sequence":"additional","affiliation":[{"name":"Nepean Clinical School, Faculty of Medicine and Health, The University of Sydney  Kingswood New South Wales Australia"},{"name":"Department of Paediatrics Nepean Hospital, Nepean Blue Mountains Local Health District  Kingswood New South Wales Australia"},{"name":"School of Medicine, University of Notre Dame Australia  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(18)30269-4"},{"issue":"3","key":"e_1_2_12_3_1","article-title":"Methylphenidate for Children and Adolescents With Attention Deficit Hyperactivity Disorder (ADHD)","volume":"3","author":"Storeb\u00f8 O. 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