{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:04:36Z","timestamp":1785323076619,"version":"3.55.0"},"reference-count":63,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Artificial intelligence (AI) is increasingly used in health care. We systematically reviewed evidence on the accuracy of AI in detecting neonatal seizures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed and CENTRAL (covering Medline, EMBASE, CINAHL and trial registries) (29 December 2025) for studies that evaluated the use of all AI applications for detecting and managing neonatal seizures, screened articles using ASReview (a MLA\u2010based platform) and assessed risk\u2010of\u2010bias using Cochrane and QUADAS 2 tools. As data precluded meta\u2010analysis, we performed narrative synthesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 26 studies out of 2051 articles. One RCT (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009258) evaluated an automated algorithm (ANSeR) and showed no differences in seizure burden (minutes) (mean difference (MD): \u221214.5, 95% CI \u221237.8, 15.9), number with seizures (risk ratio (RR) 0.86, 95% CI 0.57, 1.28) and diagnostic accuracy (%) (sensitivity: \u22128.2, 95% CI \u221225, 7.7; specificity: \u22124.8, 95% CI \u221214.1, 4.6), although higher seizure\u2010hour (%) were detected with ANSeR (difference: 20.8, 95% CI 3.6, 37.1) (low\u2010certainty evidence). Twenty\u2010five validation studies (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091021) reported MLAs with varying sensitivity (32%\u201398.6%) and specificity (70.1%\u2013100%) in seizure detection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Evidence from one RCT shows no clear improvements in seizure\u2010related outcomes, while preliminary validation studies show promising but varied MLA performances. However, most studies had small samples and significant methodological concerns including unrepresentative population and unclear reference standards, and lack of clinical validation. The current evidence is therefore insufficient to inform clinical practice. Future studies should validate the findings by enrolling representative high\u2010risk neonates and assess long\u2010term patient\u2010important outcomes.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      PROSPERO: CRD42021243455\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jpc.70513","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T10:36:21Z","timestamp":1785321381000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Use of Artificial Intelligence in Neonatal Seizure Detection: An Artificial Intelligence\u2010Assisted Systematic Review"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4204-3098","authenticated-orcid":false,"given":"Nai Ming","family":"Lai","sequence":"first","affiliation":[{"name":"School of Medicine, Faculty of Health and Medical Sciences Taylor's University  Subang Jaya Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4357-3610","authenticated-orcid":false,"given":"Kee Thai","family":"Yeo","sequence":"additional","affiliation":[{"name":"School of Medicine, Faculty of Health and Medical Sciences Taylor's University  Subang Jaya Selangor Malaysia"},{"name":"Department of Neonatology KK Women and Children's Hospital  Singapore Singapore"},{"name":"School of Women's &amp; Children's Health University of New South Wales  Randwick New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6785-425X","authenticated-orcid":false,"given":"Juin Yee","family":"Kong","sequence":"additional","affiliation":[{"name":"School of Medicine, Faculty of Health and Medical Sciences Taylor's University  Subang Jaya Selangor Malaysia"},{"name":"Department of Neonatology KK Women and Children's Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6596-7920","authenticated-orcid":false,"given":"Menghao","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Neonatology KK Women and Children's Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun Wen Huey","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Pharmacy Monash University Malaysia  Bandar Sunway Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathorn","family":"Chaiyakunapruk","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy University of Utah College of Pharmacy  Salt Lake City Utah USA"},{"name":"IDEAS Center, Veterans Affairs Salt Lake City Healthcare System  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karan","family":"Varshney","sequence":"additional","affiliation":[{"name":"Peninsula University Hospital  Frankston Victoria Australia"},{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Ovelman","sequence":"additional","affiliation":[{"name":"Cochrane Central Editorial Services  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9772-482X","authenticated-orcid":false,"given":"Kee\u2010Hsin","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine, Faculty of Health and Medical Sciences Taylor's University  Subang Jaya Selangor Malaysia"},{"name":"Post\u2010Baccalaureate Program in Nursing, College of Nursing Taipei Medical University  Taipei Taiwan"},{"name":"Cochrane Taiwan Taipei Medical University  Taipei Taiwan"},{"name":"Department of Nursing Wan Fang Hospital, Taipei Medical University  Taipei Taiwan"},{"name":"Research Center in Nursing Clinical Practice Wan Fang Hospital, Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/WNP.0b013e31826bd90d","article-title":"Neonatal Seizures and Status Epilepticus","volume":"29","author":"Abend N. 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