{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T04:57:11Z","timestamp":1790571431773,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2026,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n To explore the effects of delivery room continuous positive airway pressure (DR\u2010CPAP) in late preterm and term infants.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Systematic review and meta\u2010analysis.<\/jats:p>\n <\/jats:sec>\n \n Data Sources<\/jats:title>\n Cochrane Library, Embase, Emcare and MEDLINE were searched through March 26, 2025.<\/jats:p>\n <\/jats:sec>\n \n Eligibility Criteria<\/jats:title>\n Observational studies and randomised clinical trials (RCTs) comparing outcomes in infants receiving DR\u2010CPAP versus no DR\u2010CPAP.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Meta\u2010analyses were conducted using a random\u2010effects model to calculate pooled odds ratios (ORs) and 95% confidence intervals (CIs). Risk of bias was assessed per Cochrane guidelines, and certainty of evidence was graded using the GRADE framework.<\/jats:p>\n <\/jats:sec>\n \n Main Outcome<\/jats:title>\n Pneumothorax.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Seven studies (five non\u2010randomised, two RCTs) involving 135\u2009472 infants were included. In observational data, DR\u2010CPAP was associated with a significant increased risk of pneumothorax (unadjusted OR: 45.79; 95% CI: 31.47\u201366.63;\n moderate certainty<\/jats:italic>\n ; adjusted OR: 24.18; 95% CI: 2.32\u2013251.63;\n moderate certainty<\/jats:italic>\n ). RCTs reported no pneumothorax events in both groups, preventing meta\u2010analytic estimation. DR\u2010CPAP was also associated with increased use of surfactant in observational studies (OR: 5.68; 95% CI: 2.97\u201310.86;\n very low certainty<\/jats:italic>\n ). For neonatal intensive care unit admissions, DR\u2010CPAP was associated with significantly higher odds in observational studies (OR: 14.56; 95% CI: 13.27\u201315.98;\n moderate certainty<\/jats:italic>\n ), but significantly lower odds in RCTs (OR: 0.24; 95% CI: 0.09\u20130.63;\n very low certainty<\/jats:italic>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n DR\u2010CPAP was associated with potential harm in observational studies, though confounding cannot be excluded. Evidence from RCTs remains limited, and is of very low certainty. Well\u2010designed, robust clinical studies are urgently needed to guide practice.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jpc.70516","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:15:09Z","timestamp":1785230109000},"page":"1585-1594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Delivery Room Continuous Positive Airway Pressure and Neonatal Outcomes in Late Preterm and Term Infants: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8660-3325","authenticated-orcid":false,"given":"Yoxin","family":"Chin","sequence":"first","affiliation":[{"name":"Newborn Services Joan Kirner Women's and Children's Hospital Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maclean","family":"Hill","sequence":"additional","affiliation":[{"name":"Newborn Services Joan Kirner Women's and Children's Hospital Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Sett","sequence":"additional","affiliation":[{"name":"Newborn Services Joan Kirner Women's and Children's Hospital Melbourne Victoria Australia"},{"name":"Neonatal Research Murdoch Children's Research Institute Melbourne Victoria Australia"},{"name":"Department of Obstetrics, Gynaecology and Newborn Health The University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niranjan","family":"Thomas","sequence":"additional","affiliation":[{"name":"Newborn Services Joan Kirner Women's and Children's Hospital Melbourne Victoria Australia"},{"name":"Neonatal Research Murdoch Children's Research Institute Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6185-3694","authenticated-orcid":false,"given":"Abdul","family":"Razak","sequence":"additional","affiliation":[{"name":"Newborn Services Joan Kirner Women's and Children's Hospital Melbourne Victoria Australia"},{"name":"Department of Paediatrics Monash University Melbourne Victoria Australia"},{"name":"Monash Newborn Monash Children's Hospital Melbourne Victoria Australia"},{"name":"The Ritchie Centre Hudson Institute of Medical Research Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000895"},{"issue":"7","key":"e_1_2_14_3_1","article-title":"Non\u2010Invasive Respiratory Support in Preterm Infants as Primary Mode: A Network Meta\u2010Analysis","volume":"7","author":"Mukerji A.","year":"2025","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"7","key":"e_1_2_14_4_1","first-page":"CD014509","article-title":"Postextubation Use of Non\u2010Invasive Respiratory Support in Preterm Infants: A Network Meta\u2010Analysis","volume":"7","author":"Razak A.","year":"2025","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-3848"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.02.054"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa072788"},{"key":"e_1_2_14_8_1","volume-title":"Neonatal and Pediatric Respiratory Care","author":"Walsh B. 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