{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:44:13Z","timestamp":1792075453338,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI22\u201000661"],"award-info":[{"award-number":["PI22\u201000661"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Retinopathy of prematurity (ROP) is a neurovascular disorder that may affect not only the retina but also the brain structures involved in visual processing. The relationship between ROP severity and the volumetric development of these regions remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 157 children aged 6\u201316\u2009years, born preterm (24\u201336\u2009weeks gestational age), were assessed. Perinatal\u00a0data\u00a0and\u00a0comorbidities were collected. Brain MRI (3\u2009T) data were analysed using FreeSurfer to obtain the volumes of the thalamus, fusiform gyrus, cuneus, lingual gyrus, lateral occipital gyrus, optic chiasm and calcarine sulcus. Cognitive performance was evaluated using the WISC\u2010V. Multivariate regression analyses were adjusted for significant perinatal variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The children with severe ROP had significantly smaller bilateral thalamic volumes (left Th: 6665\u2009\u00b1\u2009672\u2009mm\n                      <jats:sup>3<\/jats:sup>\n                      vs. 7492\u2009\u00b1\u2009820\u2009mm\n                      <jats:sup>3<\/jats:sup>\n                      ;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.005) and a reduced right fusiform gyrus volume (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041) compared with those without ROP or only mildly affected. Severe ROP was also associated with lower full\u2010scale IQ scores and reduced verbal comprehension, visuospatial reasoning, and working memory indices (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.008).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Severe ROP is associated with reduced thalamic and fusiform gyrus volumes as well as with lower cognitive performance, suggesting that ROP reflects a broader neurovascular disruption affecting central visual pathways.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jpc.70536","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T07:52:27Z","timestamp":1786434747000},"page":"1931-1941","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Retinopathy of Prematurity Is Associated With Reduced Thalamic Volume and Impaired Neurodevelopment. A Cohort Study"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3519-6678","authenticated-orcid":false,"given":"Jose","family":"Uberos","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Medicine Faculty Granada University  Granada Spain"},{"name":"Neonatal Intensive Care Unit San Cecilio Clinical Hospital, Medicine Faculty  Granada Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria (ibs.GRANADA), Health Sciences Technological Park  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Carrasco\u2010Solis","sequence":"additional","affiliation":[{"name":"Neuropaediatrics Unit Paediatrics Service, San Cecilio Clinical Hospital  Granada Spain"},{"name":"Centre for Psychology and Neuropsychology (a)LPEH  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Laynez\u2010Rubio","sequence":"additional","affiliation":[{"name":"Neuropaediatrics Unit Paediatrics Service, San Cecilio Clinical Hospital  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4303-6228","authenticated-orcid":false,"given":"Ana","family":"Nieto\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria (ibs.GRANADA), Health Sciences Technological Park  Granada Spain"},{"name":"Department of Behavioural Science Methodology, Psychology Faculty Granada University  Granada Spain"},{"name":"EURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, Department of Paediatrics, Medicine Faculty Granada University  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Ruiz\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit San Cecilio Clinical Hospital, Medicine Faculty  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Contreras\u2010Chova","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Medicine Faculty Granada University  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Fern\u00e1ndez\u2010Marin","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit San Cecilio Clinical Hospital, Medicine Faculty  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6616-3879","authenticated-orcid":false,"given":"Ana","family":"Campos\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, 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