{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:44:09Z","timestamp":1792075449004,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study investigated the dynamic profile of stromal cell\u2010derived factor 4 (SDF4), a hypoxia\u2010inducible chemokine and S100B, an established astroglial injury marker, in neonates with hypoxic\u2013ischemic encephalopathy (HIE) undergoing therapeutic hypothermia (TH). Its potential as a biomarker was assessed by examining its relationship with baseline severity, clinical trajectories and metabolic recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this prospective cohort study, 33 term neonates with moderate\u2010to\u2010severe HIE treated with TH and 20 healthy controls were enrolled. Serum levels of SDF4, S100B, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI) and thiol\u2013disulphide homeostasis were measured before TH (baseline) and on Day 5 (after rewarming). Effect sizes (Cohen's\n                      <jats:italic>d<\/jats:italic>\n                      ) were calculated for significant results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Before TH, HIE infants had significantly higher SDF4, S100B, OSI and disulphide levels and lower native thiol and TAS than controls (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Following TH, all six biomarkers changed significantly in the anticipated direction across the total cohort (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.020). In stage\u2010specific sub\u2010analysis, post\u2010TH reductions in SDF4 and S100B were statistically significant only in Stage 2 HIE (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.030, respectively), whereas oxidative stress parameters (OSI, native thiol, TAS) improved significantly in both severity groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SDF4 appears to be a novel biomarker reflecting both HIE severity and the dynamic response to TH. The selective lack of SDF4 and S100B clearance in Stage 3 HIE highlights a more sustained pattern of neuroinflammatory injury, supporting SDF4's potential role in monitoring metabolic recovery and guiding individualised neuroprotective strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jpc.70545","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T03:18:02Z","timestamp":1787973482000},"page":"2019-2028","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic Hypothermia Modulates\n                    <scp>S100B<\/scp>\n                    and Oxidative Stress in Neonatal Hypoxic\u2013Ischemic Encephalopathy: Implications of\n                    <scp>SDF4<\/scp>\n                    as a Novel Biomarker"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5015-621X","authenticated-orcid":false,"given":"Fatih","family":"Isleyen","sequence":"first","affiliation":[{"name":"Department of Neonatology Sanliurfa Training and Research Hospital  Sanliurfa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0951-8258","authenticated-orcid":false,"given":"Celil","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology Sanliurfa Training and Research Hospital  Sanliurfa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9469-4757","authenticated-orcid":false,"given":"Ismail","family":"Koyuncu","sequence":"additional","affiliation":[{"name":"Departments of Medical Biochemistry, Faculty of Medicine; Science and Technology Application and Research Center Harran University  Sanliurfa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2014.3269"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/children5070099"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-023-03852-2"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2024.6613"},{"key":"e_1_2_10_6_1","first-page":"CD003311","article-title":"Cooling for Newborns With Hypoxic Ischaemic Encephalopathy","volume":"1","author":"Jacobs S. 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