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Management focuses on reducing PVR, enhancing pulmonary vasodilation, and ensuring adequate oxygen delivery. Inhaled nitric oxide (iNO), an FDA\u2010approved therapy, effectively lowers PVR and improves oxygenation in term neonates. However, in resource\u2010limited settings, its use is constrained by high costs, the need for specialized equipment, and limited availability of medical\u2010grade iNO, with industrial\u2010grade NO sometimes used despite potential impurities. These limitations have led to increased use of accessible alternatives such as sildenafil, milrinone and other vasodilators, which offer vital options where iNO is not feasible. This review highlights regional variability in management, the impact of resource constraints, and the need for equitable care. Using India as an example, a 10\u2010step approach for managing PPHN in low\u2010resource settings is proposed, alongside a call for standardized protocols and further research into both established and emerging therapies.<\/jats:p>","DOI":"10.1111\/jpc.70550","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:47:31Z","timestamp":1787654851000},"page":"1859-1872","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Managing Neonatal Pulmonary Hypertension in Low\u2010Resource Settings"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5260-0858","authenticated-orcid":false,"given":"R. 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