{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:03:18Z","timestamp":1789974198947,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1200292"],"award-info":[{"award-number":["1200292"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) is a disabling illness that frequently begins in adolescence, yet adolescents with ME\/CFS remain an under\u2010researched population. We aimed to characterise the cognitive and psychosocial wellbeing of adolescents with ME\/CFS relative to normative benchmarks and unaffected age\u2010peers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Adolescents with mild\u2010to\u2010moderate ME\/CFS (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200925) and healthy controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200925) aged 10\u201319\u2009years were recruited in Melbourne, Australia. Each completed a set of clinical questionnaires and cognitive assessments to assess ME\/CFS symptomatology, school functioning, psychosocial wellbeing and cognition. Their caregivers also completed questionnaires regarding their psychosocial wellbeing and everyday executive functioning.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Adolescents with ME\/CFS showed significantly reduced information processing speed, though other measures of intellectual functioning did not differ consistently between groups. The ME\/CFS group also reported significantly poorer sleep, quality of life and higher levels of anxiety and depression. Caregivers further identified significant attention and working memory concerns in the ME\/CFS group, but reported no differences in internalising behaviours between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Adolescents with ME\/CFS experience substantial psychosocial and physical burden because of their illness. Cognitive difficulties in ME\/CFS may reflect inefficiencies in information processing speed and fluctuating symptom burden. Discrepancies between adolescent self\u2010report and caregiver ratings underscore the importance of inclusive perspectives in ME\/CFS management. These findings support the need for flexible, paced educational and clinical accommodations and for further research into the dynamic cognitive profile of adolescents with ME\/CFS across a more representative population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jpc.70587","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:34:37Z","timestamp":1789972477000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Symptomatology, Cognition and Psychosocial Wellbeing in Adolescents With Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome: A Cross\u2010Sectional Observational Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6867-3533","authenticated-orcid":false,"given":"Tracey","family":"Chau","sequence":"first","affiliation":[{"name":"Neurodisability and Rehabilitation Research Murdoch Children's Research Institute  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4686-6331","authenticated-orcid":false,"given":"Elisha K.","family":"Josev","sequence":"additional","affiliation":[{"name":"Neurodisability and Rehabilitation Research Murdoch Children's Research Institute  Parkville Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne  Parkville Victoria Australia"},{"name":"Department of Paediatrics Mercy Hospital for Women  Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9550-0803","authenticated-orcid":false,"given":"Adam","family":"Scheinberg","sequence":"additional","affiliation":[{"name":"Victorian Paediatric Rehabilitation Service Royal Children's Hospital Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Pharmacology The University of Melbourne Bio21 Molecular Science and Biotechnology Institute  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"McDonald","sequence":"additional","affiliation":[{"name":"Department of General Medicine Royal Children's Hospital Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colette","family":"Reveley","sequence":"additional","affiliation":[{"name":"Department of Adolescent Medicine Royal Children's Hospital Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0323-449X","authenticated-orcid":false,"given":"Paul R.","family":"Gooley","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Pharmacology The University of Melbourne Bio21 Molecular Science and Biotechnology Institute  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5964-5618","authenticated-orcid":false,"given":"Christopher","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Pharmacology The University of Melbourne Bio21 Molecular Science and Biotechnology Institute  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9908-2231","authenticated-orcid":false,"given":"Sarah","family":"Knight","sequence":"additional","affiliation":[{"name":"Neurodisability and Rehabilitation Research Murdoch Children's Research Institute  Parkville Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne  Parkville Victoria Australia"},{"name":"Melbourne School of Psychological Sciences The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010014\u20100167\u20105"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00021"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsaf048"},{"issue":"16","key":"e_1_2_11_5_1","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10163603","article-title":"Health, Wellbeing, and Prognosis of Australian Adolescents With Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS): A Case\u2010Controlled Follow\u2010Up Study","volume":"10","author":"Josev E. K.","year":"2021","journal-title":"Journal of Clinical Medicine"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2018.00302"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2022.111063"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.143032"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000550"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2016.02.002"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs20110241"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.162.12.1196"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682\u2010019\u201000119\u20102"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102024\u2010089038"},{"key":"e_1_2_11_15_1","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen J.","year":"1988"},{"key":"e_1_2_11_16_1","unstructured":"W.LenhardandA.Lenhard \u201cPsychometrica: Computation of Effect Sizes \u201d2022 https:\/\/www.psychometrica.de\/effect_size.html."},{"issue":"1","key":"e_1_2_11_17_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing","volume":"57","author":"Benjamini Y.","year":"1995","journal-title":"Journal of the Royal Statistical Society. Series B, Statistical Methodology"},{"issue":"12","key":"e_1_2_11_18_1","first-page":"16","article-title":"Pain, Pain, Go Away: Antidepressants and Pain Management","volume":"5","author":"Sansone R. A.","year":"2008","journal-title":"Psychiatry (Edgmont)"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsad177"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.6722"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/clep.S96797"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.12425"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2017.00121"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.70587","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jpc.70587","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.70587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:34:39Z","timestamp":1789972479000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.70587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,20]]},"references-count":22,"alternative-id":["10.1111\/jpc.70587"],"URL":"https:\/\/doi.org\/10.1111\/jpc.70587","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"value":"1034-4810","type":"print"},{"value":"1440-1754","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,20]]},"assertion":[{"value":"2026-05-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jpc.70587"}}