{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:06:34Z","timestamp":1789189594372,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Complete blood count (CBC)\u2010derived inflammatory markers are readily available, inexpensive indices of systemic inflammation. This study evaluated their association with mortality in a heterogeneous neonatal intensive care unit (NICU) population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective observational study included neonates admitted to a mixed level II and III NICU between 2022 and 2026. Neutrophil\u2010to\u2010lymphocyte ratio (NLR), platelet\u2010to\u2010lymphocyte ratio (PLR), systemic immune\u2010inflammation index (SII) and systemic inflammatory response index (SIRI) were calculated from admission CBCs. Associations with in\u2010hospital mortality were assessed using logistic regression and sensitivity analyses. Discriminatory performance was evaluated using receiver operating characteristic analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 530 neonates, 45 (8.5%) died. SII and SIRI were significantly lower in nonsurvivors, whereas NLR and PLR did not differ between groups. After adjusting for gestational age, PLR was associated with mortality (aOR, 0.381; 95% CI, 0.151\u20130.960;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041), whereas NLR, SII and SIRI were not. The PLR association persisted after additional adjustment for culture\u2010confirmed early\u2010onset sepsis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039) but was attenuated and was no longer statistically significant when birth weight replaced gestational age (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.065). Standalone discrimination was poor for all indices (AUCs, 0.517\u20130.609), although SII showed statistically significant, albeit weak, discriminatory performance (AUC, 0.609; 95% CI, 0.529\u20130.689;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Admission CBC\u2010derived inflammatory indices showed limited associations with mortality and poor standalone discriminatory performance. The association between PLR and mortality was sensitive to the choice of adjustment variable and warrants confirmation in prospective multicentre studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jpc.70594","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:16:12Z","timestamp":1789186572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Admission Complete Blood Count\u2010Derived Inflammatory Markers and Mortality in Neonatal Intensive Care Unit Patients: A Retrospective Observational Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0299-0725","authenticated-orcid":false,"given":"Ayberk","family":"\u00d6zkavakl\u0131","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Bah\u00e7e\u015fehir University  \u0130stanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2427-5228","authenticated-orcid":false,"given":"Bengisu","family":"\u00c7a\u011fl\u0131altuncu","sequence":"additional","affiliation":[{"name":"Bah\u00e7e\u015fehir University, Faculty of Medicine  \u0130stanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7442-9534","authenticated-orcid":false,"given":"Fatih","family":"Fakirullaho\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Bah\u00e7e\u015fehir University  \u0130stanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9000-4733","authenticated-orcid":false,"given":"Mahmut","family":"Kara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Bah\u00e7e\u015fehir University  \u0130stanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3613-0814","authenticated-orcid":false,"given":"Hatice G\u00fclhan","family":"S\u00f6zen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Department of Pediatric Neurology, Faculty of Medicine Bah\u00e7e\u015fehir University  \u0130stanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3825-858X","authenticated-orcid":false,"given":"Bora","family":"Baysal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Department of Neonatal Intensive Care Unit, Faculty of Medicine Bah\u00e7e\u015fehir University  \u0130stanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.5350\/SEMB2013470104"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887\u2010025\u201006390\u20101"},{"key":"e_1_2_13_4_1","first-page":"19","article-title":"Risk Factors for Neonatal Death in Neonatal Intensive Care Unit According to Survival Analysis","volume":"22","author":"Risso S. d. 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