{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:58:08Z","timestamp":1790675888230,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n This study investigated the efficacy of the\n MIND\u2010DASE<\/jats:italic>\n (\n M<\/jats:italic>\n editerranean\u2010style\n I<\/jats:italic>\n ntervention for\n N<\/jats:italic>\n euro\u2010\n D<\/jats:italic>\n evelopmental\n D<\/jats:italic>\n iversity and\n A<\/jats:italic>\n utism\n S<\/jats:italic>\n ymptom\n E<\/jats:italic>\n valuation) nutritional model in children with autism spectrum disorder (ASD). We hypothesized that increasing dietary diversity acts as a clinical catalyst for rapid behavioural improvement.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In this propensity score\u2010matched retrospective cohort study (\n N<\/jats:italic>\n \u2009=\u2009188), children in the diet group (\n n<\/jats:italic>\n \u2009=\u200994) were matched 1:1 with non\u2010compliant controls (\n n<\/jats:italic>\n \u2009=\u200994) based on age, gender and baseline symptom severity (ATEC\/ABC). Behavioural and developmental outcomes were assessed at baseline, 6 and 12\u2009months.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n At 6\u2009months, the MIND\u2010DASE group demonstrated a significantly more rapid reduction in Aberrant Behavior Checklist (ABC) total scores compared to controls (\u221218.4\u2009\u00b1\u200921.7 vs. \u22123.6\u2009\u00b1\u200916.2;\n p<\/jats:italic>\n \u2009<\u20090.0001). Significant superiority was observed across all ABC subscales, including irritability (\n p<\/jats:italic>\n \u2009=\u20090.0001) and hyperactivity (\n p<\/jats:italic>\n \u2009=\u20090.0001). While both groups showed significant developmental progress in ATEC scores by the 12\u2010month mark, the dietary intervention induced a markedly earlier clinical response in behavioural symptoms within the first 6\u2009months.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The MIND\u2010DASE model induces a rapid and significant improvement in aberrant behaviours. While long\u2010term standard care eventually leads to developmental gains, the nutritional intervention serves as a critical catalyst, accelerating clinical improvement in the early stages of treatment.<\/jats:p>\n \n Trial Registration:<\/jats:bold>\n This study was registered at\n ClinicalTrials.gov<\/jats:ext-link>\n identifier: NCT06662916\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jpc.70606","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:20:01Z","timestamp":1790673601000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of a Novel Mediterranean\u2010Style Diet (\n MIND<\/scp>\n \u2010\n DASE<\/scp>\n ) on Behavioural and Developmental Outcomes in Children With Autism Spectrum Disorder: A Propensity Score\u2010Matched Analysis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6365-1124","authenticated-orcid":false,"given":"Hanim Seyma","family":"Topuz","sequence":"first","affiliation":[{"name":"Autism Nutrition and Research Center, Department of Pediatrics University of Health Sciences Turkey, Ba\u015fak\u015fehir \u00c7am ve Sakura City Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Eren","family":"Kurnaz","sequence":"additional","affiliation":[{"name":"Autism Nutrition and Research Center, Department of Pediatrics University of Health Sciences Turkey, Ba\u015fak\u015fehir \u00c7am ve Sakura City Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyup Sabri","family":"Keles","sequence":"additional","affiliation":[{"name":"Fresno. Department of Pediatrics, Pediatric Critical Care Medicine University of California San Francisco (UCSF) Fresno California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atilla","family":"Ersen","sequence":"additional","affiliation":[{"name":"Autism Nutrition and Research Center, Department of Pediatrics University of Health Sciences Turkey, Ba\u015fak\u015fehir \u00c7am ve Sakura City Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9676-7086","authenticated-orcid":false,"given":"Hasan","family":"Onal","sequence":"additional","affiliation":[{"name":"Autism Nutrition and Research Center, Department of Pediatrics University of Health Sciences Turkey, Ba\u015fak\u015fehir \u00c7am ve Sakura City Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.05.046"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020423"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201040336\u20104"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.10.015"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.65"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980018003762"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2021.01.003"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803\u2010018\u20103699\u20102"},{"issue":"52","key":"e_1_2_13_10_1","first-page":"77","article-title":"Sorun Davran\u0131\u015flar Kontrol Listesi T\u00fcrk\u00e7e Formu'nun psikometrik \u00f6zelliklerinin incelenmesi","volume":"18","author":"Sucuo\u011flu B.","year":"2003","journal-title":"T\u00fcrk Psikoloji Dergisi"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10578\u2010008\u20100108\u20107"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.03.002"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.76"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.4144"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes14030677"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2015.10.006"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2016.269"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.22860"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803\u2010021\u201004947\u20104"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.2972"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32952"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.70606","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jpc.70606","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.70606","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:20:02Z","timestamp":1790673602000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.70606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":20,"alternative-id":["10.1111\/jpc.70606"],"URL":"https:\/\/doi.org\/10.1111\/jpc.70606","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"value":"1034-4810","type":"print"},{"value":"1440-1754","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]},"assertion":[{"value":"2026-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jpc.70606"}}