{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:59:37Z","timestamp":1790679577415,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R03DK140423\u201001A1"],"award-info":[{"award-number":["1R03DK140423\u201001A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["LRP 2L40DK130152\u201002"],"award-info":[{"award-number":["LRP 2L40DK130152\u201002"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Urinary tract infections (UTIs) are among the most common bacterial infections and pose a significant global health challenge in children. UTIs can cause a range of conditions from cystitis and pyelonephritis to bacteraemia. Current methods for diagnosing UTI lack adequate sensitivity and specificity and are time\u2010consuming, driving demand for improved approaches. Although most UTIs resolve with antibiotic therapy, some children develop recurrent UTIs due to multidrug\u2010resistant organisms and progressive chronic kidney disease. Currently, there are no reliable methods to identify which children are at risk for adverse outcomes, representing a critical gap in paediatric UTI management. This review explores how bioinformatic approaches can offer a comprehensive framework to harness scientific discoveries and meet clinical challenges posed by paediatric UTI. Recent advances in high\u2010throughput sequencing and proteomics have generated extensive datasets, enabling detailed analysis of microbial and host responses during UTI. We summarize how computational and multi\u2010omics approaches, including metagenomics, bulk and single\u2010cell transcriptomics, proteomics, epigenetics and integrative frameworks, have deepened our understanding of UTI pathogenesis and the foundational determinants of a successful host response. We consider the collective potential of these discoveries and technologies to transform future UTI management.<\/jats:p>","DOI":"10.1111\/jpc.70607","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:28:57Z","timestamp":1790677737000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Leveraging Bioinformatic Strategies to Advance Care of Children With Urinary Tract Infections"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1456-335X","authenticated-orcid":false,"given":"Xin","family":"Wang","sequence":"first","affiliation":[{"name":"The Kidney and Urinary Tract Center Abigail Wexner Research Institute at Nationwide Children's  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4935-1799","authenticated-orcid":false,"given":"Rishil H.","family":"Patel","sequence":"additional","affiliation":[{"name":"The Kidney and Urinary Tract Center Abigail Wexner Research Institute at Nationwide Children's  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7317-5168","authenticated-orcid":false,"given":"Qiushi","family":"Li","sequence":"additional","affiliation":[{"name":"The Kidney and Urinary Tract Center Abigail Wexner Research Institute at Nationwide Children's  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3396-4215","authenticated-orcid":false,"given":"Christina B.","family":"Ching","sequence":"additional","affiliation":[{"name":"The Kidney and Urinary Tract Center Abigail Wexner Research Institute at Nationwide Children's  Columbus Ohio USA"},{"name":"Department of Urology Nationwide Children's Hospital  Columbus Ohio USA"},{"name":"Department of Pediatrics The Ohio State University College of Medicine  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4056-3030","authenticated-orcid":false,"given":"Laura","family":"Schwartz","sequence":"additional","affiliation":[{"name":"The Kidney and Urinary Tract Center Abigail Wexner Research Institute at Nationwide Children's  Columbus Ohio USA"},{"name":"Department of Pediatrics The Ohio State University College of Medicine  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6429-9086","authenticated-orcid":false,"given":"Juan de Dios Ruiz\u2010","family":"Rosado","sequence":"additional","affiliation":[{"name":"The Kidney and Urinary Tract Center Abigail Wexner Research Institute at Nationwide Children's  Columbus Ohio USA"},{"name":"Department of Pediatrics The Ohio State University College of Medicine  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5509-7135","authenticated-orcid":false,"given":"John David","family":"Spencer","sequence":"additional","affiliation":[{"name":"The Kidney and Urinary Tract Center Abigail Wexner Research Institute at Nationwide Children's  Columbus Ohio USA"},{"name":"Department of Pediatrics The Ohio State University College of Medicine  Columbus Ohio USA"},{"name":"Division of Nephrology and Hypertension, Department of Pediatrics Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2750-4415","authenticated-orcid":false,"given":"Brian","family":"Becknell","sequence":"additional","affiliation":[{"name":"The Kidney and Urinary Tract Center Abigail Wexner Research Institute at Nationwide Children's  Columbus Ohio USA"},{"name":"Department of Pediatrics The Ohio State University College of Medicine  Columbus Ohio USA"},{"name":"Division of Nephrology and Hypertension, Department of Pediatrics Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2022.888205","article-title":"Disease Burden and Long\u2010Term Trends of Urinary Tract Infections: A Worldwide Report","volume":"10","author":"Yang X.","year":"2022","journal-title":"Frontiers in Public Health"},{"issue":"10237","key":"e_1_2_15_3_1","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/S0140-6736(20)30676-0","article-title":"Urinary Tract Infections in Children","volume":"395","author":"Tullus K.","year":"2020","journal-title":"Lancet"},{"issue":"5","key":"e_1_2_15_4_1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nrmicro3432","article-title":"Urinary Tract Infections: Epidemiology, Mechanisms of Infection and Treatment Options","volume":"13","author":"Flores\u2010Mireles A. 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