{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:28:46Z","timestamp":1792427326636,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T00:00:00Z","timestamp":1698883200000},"content-version":"vor","delay-in-days":62,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/P005918\/1"],"award-info":[{"award-number":["MR\/P005918\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Public Health Dent"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Childhood caries is associated with poorer self\u2010rated general health in adulthood, but it remains unclear whether that holds for physical health and aging. The aim of this study was to identify whether age\u20105 caries is associated with (a) biomarkers for poor physical health, and (b) the pace of aging (PoA) by age 45\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants are members of the Dunedin Multidisciplinary Health and Development Study birth cohort. At age 45, 94.1% (<jats:italic>n<\/jats:italic>\u2009=\u2009938) of those still alive took part. Data on age\u20105 caries experience and age\u201045 health biomarkers were collected. The PoA captures age\u2010related decline across the cardiovascular, metabolic, renal, immune, dental and pulmonary systems from age 26 to 45\u2009years. We used (a) generalized estimating equations to examine associations between age\u20105 caries and poor physical health by age 45\u2009years, and (b) ordinary least squares regression to examine whether age\u20105 caries was associated with the PoA. Analyses adjusted for sex, perinatal health, childhood SES and childhood IQ.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>High caries experience at age\u20105 was associated with higher risk for some metabolic abnormalities, including BMI \u226530, high waist circumference, and high serum leptin. Those with high caries experience at age\u20105 were aging at a faster rate by age 45\u2009years than those who had been caries\u2010free.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Oral health is essential for wellbeing. Poor oral health can be an early signal of a trajectory towards poor health in adulthood. Management for both conditions should be better\u2010integrated; and integrated population\u2010level prevention strategies should be foundational to any health system.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jphd.12591","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T06:15:07Z","timestamp":1698992107000},"page":"381-388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Childhood caries is associated with poor health and a faster pace of aging by midlife"],"prefix":"10.1111","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1340-2944","authenticated-orcid":false,"given":"Bego\u00f1a","family":"Ruiz","sequence":"first","affiliation":[{"name":"Sir John Walsh Research Institute, Department of Oral Sciences, Faculty of Dentistry University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8905-398X","authenticated-orcid":false,"given":"Jonathan M.","family":"Broadbent","sequence":"additional","affiliation":[{"name":"Sir John Walsh Research Institute, Department of Oral Sciences, Faculty of Dentistry University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0588-6843","authenticated-orcid":false,"given":"W. Murray","family":"Thomson","sequence":"additional","affiliation":[{"name":"Sir John Walsh Research Institute, Department of Oral Sciences, Faculty of Dentistry University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandhya","family":"Ramrakha","sequence":"additional","affiliation":[{"name":"Dunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, Division of Sciences University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terrie E.","family":"Moffitt","sequence":"additional","affiliation":[{"name":"Department of Psychology and Neuroscience Duke University  Durham North Carolina USA"},{"name":"Department of Psychiatry and Behavioral Sciences Duke University Medical Center  Durham North Carolina USA"},{"name":"Center for Genomic and Computational Biology Duke University  Durham North Carolina USA"},{"name":"Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry Kings College London  London USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avshalom","family":"Caspi","sequence":"additional","affiliation":[{"name":"Department of Psychology and Neuroscience Duke University  Durham North Carolina USA"},{"name":"Department of Psychiatry and Behavioral Sciences Duke University Medical Center  Durham North Carolina USA"},{"name":"Center for Genomic and Computational Biology Duke University  Durham North Carolina USA"},{"name":"Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry Kings College London  London USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richie","family":"Poulton","sequence":"additional","affiliation":[{"name":"Dunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, Division of Sciences University of Otago  Dunedin New 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