{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:38:54Z","timestamp":1791913134426,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T00:00:00Z","timestamp":1725667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001024","name":"Roy J. Carver Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Public Health Dent"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the relationships between longitudinal fluoride intakes and bone densitometry outcomes in young adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were analyzed from the Iowa Fluoride Study and Iowa Bone Development Study, which followed 1,882 infants from birth in 1992. Daily fluoride intakes were assessed using detailed questionnaires sent every 1.5\u20136\u2009months, and multi\u2010row detector computed tomography (MDCT) scans of distal tibia were obtained from 330 participants aged 23\u2009years. Sex\u2010specific bivariate and multivariable associations with MDCT outcomes were examined using linear regression. Because of the multiple statistical analyses being conducted, <jats:italic>p<\/jats:italic>\u2010values\u2009&lt;\u20090.01 were considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In fully adjusted analyses, no statistically significant (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) or suggestive (0.01\u2009&lt;\u2009<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) associations were found between period\u2010specific or cumulative fluoride intake and bone measures for either sex, although there were suggestive positive relationships in unadjusted analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Longitudinal fluoride intakes had little association with bone measures at age 23. As there were no adverse effects from fluoride intake on bone health in young adults, results support the continued use of fluorides, particularly community water fluoridation is the most cost\u2010effective method of dental caries prevention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jphd.12643","type":"journal-article","created":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T11:39:37Z","timestamp":1725709177000},"page":"428-438","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Associations between longitudinal fluoride intakes from birth to age 23 and multi\u2010row detector computed tomography bone densitometry outcomes at age 23"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8592-4382","authenticated-orcid":false,"given":"Gurjot Kaur","family":"Bhatia","sequence":"first","affiliation":[{"name":"Department of Preventive and Community Dentistry, College of Dentistry The University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9150-4199","authenticated-orcid":false,"given":"Steven M.","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Preventive and Community Dentistry, College of Dentistry The University of Iowa  Iowa City Iowa USA"},{"name":"Department of Epidemiology, College of Public Health The University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0090-9973","authenticated-orcid":false,"given":"John J.","family":"Warren","sequence":"additional","affiliation":[{"name":"Department of Preventive and Community Dentistry, College of Dentistry The University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar A.","family":"Rysavy","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Computational Biology, College of Dentistry The University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Punam K.","family":"Saha","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, College of Engineering The University of Iowa  Iowa City Iowa USA"},{"name":"Department of Radiology, Carver College of Medicine The University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoliu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, College of Engineering The University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erliang","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Preventive and Community Dentistry, College of Dentistry The University of Iowa  Iowa City Iowa USA"},{"name":"Division of Biostatistics and Computational Biology, College of Dentistry The University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,7]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"National Institute of Dental and Craniofacial Research (NIDCR). 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