{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T10:43:31Z","timestamp":1756464211780,"version":"3.37.3"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"China National Natural Science Foundation","doi-asserted-by":"crossref","award":["81172974","30973667"],"award-info":[{"award-number":["81172974","30973667"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Jiangsu Province \u2018Qing Lan Project\u2019"},{"name":"Jiangsu Province \u2018333 High-level Talents Cultivation Project\u2019"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The aim of this study was to characterize the conformation and potency of a mutated glucagon-like peptide-1 (mGLP-1), and evaluate its glucose-lowering activity in diabetic mice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Spectroscopy techniques were employed to characterize the conformation of mGLP-1. Glucose tolerance test was performed to determine the potency of mGLP-1 in vivo. A mouse model in which diabetes was induced by multiple low doses of streptozotocin was established to evaluate the glucose-lowering activity of mGLP-1.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>Compared with native GLP-1, mGLP-1 had a similar conformation and an enhanced potency in vivo. In diabetic mice, mGLP-1 displayed a significantly improved glucose-lowering activity as judged by fasting glucose and insulin, oral glucose tolerance test, beta cell function analysis and histochemical analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Collectively, mGLP-1 possesses an improved glucose-lowering activity in vivo and therefore can be recognized as a potential candidate for the future development of anti-diabetic drugs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.12011","type":"journal-article","created":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T04:41:42Z","timestamp":1353386502000},"page":"539-546","source":"Crossref","is-referenced-by-count":2,"title":["A mutated glucagon-like peptide-1 with improved glucose-lowering activity in diabetic mice"],"prefix":"10.1093","volume":"65","author":[{"given":"Mingming","family":"Gao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University , Nanjing,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Tong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University , Nanjing,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangdong","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University , Nanjing,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbing","family":"Yao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural 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