{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:12:48Z","timestamp":1777457568523,"version":"3.51.4"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa Cient\u00edfica e Tecnol\u00f3gica do Estado de Santa Catarina"},{"DOI":"10.13039\/100017593","name":"Universidade do Vale do Itaja\u00ed","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100017593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study has aimed to assess the mechanisms of action for the gastroprotective effect of the acetone extract (PCAE) and methanol fraction (PCMF) of Polygala cyparissias, as well as to evaluate the activity of 1,3,6,8-tetrahydroxy-2,7-dimethoxyxanthone (1), 1,7-dihydroxy-2,3-dimethoxyxanthone (2) and astragalin (3).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Gastric secretion and mucus content were determined by pylorus ligation in mice. Nitric oxide (NO) and sulfhydryl group participation were observed by the pretreatment of mice with L-NAME or NEM. Acute ulcer was induced by ethanol\/HCl and chronic ulcer by acetic acid. Anti-Helicobacter pylori activity was evaluated by the agar solid dilution assay.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>Neither PCAE nor PCMF had the ability to reduce H+ concentration. However, both of them enhanced mucus secretion. PCAE demonstrated its gastroprotection in a NO-dependent manner, while PCMF exerted the activity depending on the sulfhydryl group. In chronic ulcer, the curative ratios for the PCAE and PCMF were 67.5 and 58.4%, respectively. No effect over H. pylori was detected. Compounds 1, 2 and 3 were able to reduce lesions in the order of 79.6, 73.8 and 67.6%, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The data suggested that PCAE and PCMF displayed antiulcer activity due to different mechanisms and with the participation of phenolic compounds obtained from the plant.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.12038","type":"journal-article","created":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T11:53:15Z","timestamp":1361879595000},"page":"767-776","source":"Crossref","is-referenced-by-count":12,"title":["Role of gastric mucus secretion, oxinitrergic system and sulfhydryl groups on the gastroprotection elicited by <i>Polygala cyparissias<\/i> (Polygalaceae) in mice"],"prefix":"10.1093","volume":"65","author":[{"given":"Luiz Carlos","family":"Klein-J\u00fanior","sequence":"first","affiliation":[{"name":"Programa 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Itaja\u00ed,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodoro Marcel","family":"Wagner","sequence":"additional","affiliation":[{"name":"N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR), Universidade do Vale do Itaja\u00ed-UNIVALI , Itaja\u00ed,","place":["Brazil"]},{"name":"Departamento de Farm\u00e1cia, Universidade da Regi\u00e3o de Joinville , Joinville,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania Mari Bell\u00e9","family":"Bresolin","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Universidade do Vale do Itaja\u00ed-UNIVALI , Itaja\u00ed,","place":["Brazil"]},{"name":"N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR), Universidade do Vale do Itaja\u00ed-UNIVALI , 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