{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:38:57Z","timestamp":1762673937894,"version":"3.28.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Italian Ministry of University and Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>In this work was to evaluate the cytotoxic activity of a series of monomeric group 3 and lanthanide (N,N,N)-heteroscorpionate-triflate complexes (M (OTf) 2 (cybpamd) (THF)) (Ln = Sc (2), Y (3), La (4), Nd (5), Sm (6), Dy (7), Yb (8); OTf = SO3CF3; cybpamd = N, N\u2032-dicyclohexyl-2,2-bis-(3,5-dimethyl-pyrazol-1-yl)-acetamidinate) having octahedral geometry around the metal atoms on the human epithelial lung adenocarcinoma (A549), human melanoma (A375), human cervical epithelial adenocarcinoma, human embryonic kidney (HEK-293) and murine macrophages (J774.A1) cell lines.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>All the tested compounds were incubated with cells for 72 h and their growth inhibition assessed by using MTT assay.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>On the cell line HEK-293 complexes 5 and 7 show a reasonable activities, while the murine macrophage cell line (J774.A1), only the scandium 2 complex is not very active. All complexes tested are poorly active on human health adenocarcinoma lung epithelial (A549) and human melanoma (A375).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The group 3 and lanthanide (N,N,N)-heteroscorpionate triflate-complexes (M(OTf)2(cybpamd)(THF)) on murine macrophage (J774.A1) cell line, except that of scandium, show a reasonable activity. On human epithelial cervix adenocarcinoma (HeLa) complexes 3, 5 and 6 are significantly more active than cis-platinum, as well as complex 5 is more active on human embryonic kidney (HEK-293) cell line. All the tested complexes are poorly active on human epithelial lung adenocarcinoma (A549) and human melanoma (A375).<\/jats:p>\n                  <jats:p>The different behaviour of the complexes examined (2\u20138) let us hypothesize that the cytotoxic activity is related to the molecule as a whole and not only to the ligand or the metal ion separately.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.12112","type":"journal-article","created":{"date-parts":[[2013,7,31]],"date-time":"2013-07-31T03:11:54Z","timestamp":1375240314000},"page":"1354-1359","source":"Crossref","is-referenced-by-count":6,"title":["New insights on cytotoxic activity of group 3 and lanthanide compounds: complexes with [N,N,N]-scorpionate ligands"],"prefix":"10.1093","volume":"65","author":[{"given":"Carmela","family":"Saturnino","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Farmaceutiche, Universit\u00e0 di Salerno , Fisciano,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Bortoluzzi","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Molecolari e Nanosistemi, Universit\u00e0 Ca' Foscari di Venezia , Venezia,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariagrazia","family":"Napoli","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica, Universit\u00e0 di Salerno , Fisciano,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ada","family":"Popolo","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Farmaceutiche, Universit\u00e0 di Salerno , Fisciano,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo","family":"Pinto","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Farmaceutiche, Universit\u00e0 di Salerno , 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