{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T04:09:33Z","timestamp":1730434173216,"version":"3.28.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Syngonanthus macrolepis, popularly known in Brazil as \u2018sempre-vivas\u2019, is a plant from the family Eriocaulaceae, it is found in the states of Minas Gerais and Bahia. The species contains a variety of constituents, including flavonoids with gastroprotective effect. In this work, a flavonoid-rich fraction (Sm-FRF) obtained from scapes of S. macrolepis was investigated for preventing gastric ulceration in mice and rats.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The activity was evaluated in models of induced gastric ulcer (absolute ethanol, stress, non-steroidal anti-inflammatory drugs and pylorus ligation). The cytoprotective mechanisms of the Sm-FRF in relation to sulfhydryl (SH) groups, nitric oxide (NO) and antioxidant enzymes were also evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>The Sm-FRF (100 mg\/kg, p.o.) significantly reduced gastric injury in all models, and did not alter gastric juice parameters after pylorus ligation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The results indicate significant gastroprotective activity for the Sm-FRF, which probably involves the participation of both SH groups and the antioxidant system. Both are integral parts of the gastrointestinal mucosa's cytoprotective mechanisms against aggressive factors.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.12175","type":"journal-article","created":{"date-parts":[[2013,11,18]],"date-time":"2013-11-18T02:38:33Z","timestamp":1384742313000},"page":"445-452","source":"Crossref","is-referenced-by-count":7,"title":["Gastroprotective effects (in rodents) of a flavonoid rich fraction obtained from <i>Syngonanthus macrolepsis<\/i>"],"prefix":"10.1093","volume":"66","author":[{"given":"Le\u00f4nia Maria","family":"Batista","sequence":"first","affiliation":[{"name":"Departamento de Ci\u00eancias Farmac\u00eauticas, Centro de Ci\u00eancias da Sa\u00fade, Laborat\u00f3rio de Farmacologia do Trato Gastrintestinal, Universidade Federal da Para\u00edba (UFPB) , Jo\u00e3o Pessoa, PB,","place":["Brazil"]},{"name":"Departamento de Fisiologia e Biof\u00edsica, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP) , Campinas, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Beatriz Albino","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia e Biof\u00edsica, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP) , Campinas, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gedson Rodrigues","family":"de Morais Lima","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Farmac\u00eauticas, Centro de Ci\u00eancias da Sa\u00fade, Laborat\u00f3rio de Farmacologia do Trato Gastrintestinal, Universidade Federal da Para\u00edba (UFPB) , Jo\u00e3o Pessoa, PB,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heloina","family":"de Sousa Falc\u00e3o","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Farmac\u00eauticas, Centro de Ci\u00eancias da Sa\u00fade, Laborat\u00f3rio de Farmacologia do Trato Gastrintestinal, Universidade Federal da Para\u00edba (UFPB) , Jo\u00e3o Pessoa, PB,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana","family":"de Pietro Magri","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia e Biof\u00edsica, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP) , Campinas, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anderson","family":"Luiz-Ferreira","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia e Biof\u00edsica, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP) , Campinas, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes Campaner","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e2nica, Instituto de Qu\u00edmica, Universidade Estadual Paulista (UNESP) , Araraquara, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e9lia Akiko","family":"Hiruma-Lima","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia, Instituto de Bioci\u00eancias, Universidade Estadual Paulista , Botucatu, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wagner","family":"Vilegas","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e2nica, Instituto de Qu\u00edmica, Universidade Estadual Paulista (UNESP) , Araraquara, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba Regina Monteiro","family":"Souza Brito","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia e Biof\u00edsica, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP) , Campinas, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,3,1]]},"reference":[{"key":"2024103109154825900_jphp12175-cit-0001","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1365-2036.2008.03610.x","article-title":"Systematic review: ulcer definition in NSAID ulcer prevention trials","volume":"27","author":"Yeomans","year":"2008","journal-title":"Aliment Pharmacol Ther"},{"key":"2024103109154825900_jphp12175-cit-0002","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1177\/153537020623100202","article-title":"Gastrointestinal inflammation: a central component of mucosal defence and repair","volume":"231","author":"Martin","year":"2006","journal-title":"Exp Biol Med"},{"key":"2024103109154825900_jphp12175-cit-0003","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.jep.2012.09.019","article-title":"Evaluation of antiulcer activity and mechanism of action of methanol stem bark extract of Lafoensia pacari A. 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