{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T03:56:34Z","timestamp":1785297394802,"version":"3.55.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Key Project of National Natural Science Foundation of China, P.R. China","award":["81130071"],"award-info":[{"award-number":["81130071"]}]},{"name":"National Key Scientific Project for New Drug Discovery and Development, P.R. 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Forced swimming test (FST) and tail suspension test (TST) were used to determine the antidepressant-like activity of XCHT in mice and rats. The possible mechanism of XCHT was elucidated by the reserpine-induced hypothermia and 5-hydroxytryptophan (5-HTP)-induced head-twitch in mice. The levels of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were measured in prefrontal cortex and hippocampus tissue of both mice and rats. Moreover, the extracellular 5-HT in rat hippocampus was assessed by using microdialysis coupled to HPLC with electrochemical detection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>Forty-four components were detected in XCHT. XCHT significantly reduced immobility time in the TST and the FST, antagonized reserpine-induced depressive-like behaviours, increased 5-HTP-induced head-twitches, elevated 5-HT and 5-HIAA levels, and increased 5-HT turnover at doses that did not affect general activity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These data demonstrate that XCHT has therapeutic effects in animal models of depression by enhancing the serotoninergic system in the prefrontal cortex and hippocampus.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.12201","type":"journal-article","created":{"date-parts":[[2013,12,23]],"date-time":"2013-12-23T02:34:41Z","timestamp":1387766081000},"page":"823-834","source":"Crossref","is-referenced-by-count":30,"title":["Xiaochaihutang prevents depressive-like behaviour in rodents by enhancing the serotonergic system"],"prefix":"10.1093","volume":"66","author":[{"given":"Guang Yue","family":"Su","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Shenyang Pharmaceutical University , Shenyang,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing Yu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Shenyang Pharmaceutical University , Shenyang,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Shenyang Pharmaceutical University , Shenyang,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi Li","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis, Shenyang Pharmaceutical University , Shenyang,","place":["PR 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