{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:52:09Z","timestamp":1769734329027,"version":"3.49.0"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"University of Reading, UK"},{"name":"Tishreen University, Syria"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The search for agents that are capable of preventing restenosis and reduce the risk of late thrombosis is of utmost importance. In this study we aim to evaluate the in vitro effects of ibuprofen on proliferation and migration of human coronary artery smooth muscle cells and on endothelial cells.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Cell proliferation was evaluated by trypan blue exclusion. Cell migration was assessed by wound-healing \u2018scratch\u2019 assay and time-lapse video microscopy. Protein expression was assessed by immunoblotting, and morphology by immunocytochemistry. The involvement of the PPAR\u03b3 pathway was studied with the agonist troglitazone, and the use of selective antagonists such as PGF2\u03b1 and GW9662.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>We demonstrate that ibuprofen inhibits proliferation and migration of HCASMCs and induces a switch in HCASMCs towards a differentiated and contractile phenotype, and that these effects are mediated through the PPAR\u03b3 pathway. Importantly we also show that the effects of ibuprofen are cell type-specific as it does not affect migration and proliferation of endothelial cells.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Taken together, our results suggest that ibuprofen could be an effective drug for the development of novel drug-eluting stents that could lead to reduced rates of restenosis and potentially other complications of DES implantation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.12203","type":"journal-article","created":{"date-parts":[[2014,1,20]],"date-time":"2014-01-20T11:18:53Z","timestamp":1390216733000},"page":"779-792","source":"Crossref","is-referenced-by-count":6,"title":["Ibuprofen inhibits migration and proliferation of human coronary artery smooth muscle cells by inducing a differentiated phenotype: role of peroxisome proliferator-activated receptor \u03b3"],"prefix":"10.1093","volume":"66","author":[{"given":"Abeer","family":"Dannoura","sequence":"first","affiliation":[{"name":"School of Pharmacy, University of Reading , Reading,","place":["UK"]},{"name":"Institute for Cardiovascular and Metabolic Research, University of Reading , Reading,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Giraldo","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Reading , Reading,","place":["UK"]},{"name":"Institute for Cardiovascular and Metabolic Research, University of Reading , Reading,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ines","family":"Pereira","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Reading , Reading,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan M","family":"Gibbins","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Reading , Reading,","place":["UK"]},{"name":"Institute for Cardiovascular and Metabolic Research, University of Reading , Reading,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phil R","family":"Dash","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Reading , Reading,","place":["UK"]},{"name":"Institute for Cardiovascular and Metabolic Research, University of Reading , Reading,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrina A","family":"Bicknell","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Reading , Reading,","place":["UK"]},{"name":"Institute for Cardiovascular and Metabolic Research, University of Reading , 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