{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:17:11Z","timestamp":1761513431725,"version":"3.28.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Proton pump inhibitors as adjunctive therapy would improve diabetes control and could enhance the hypoglycaemic activity of DPP-4 inhibitors. The aim of the study was to investigate the short-term effects of lansoprazole (LPZ), sitagliptin (SITA) and their combination therapy on glucose regulation and gut peptide secretion.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Glucose and gut peptide were determined and compared after short-term administration of LPZ or SITA, or in combination to mice with diet-induced obesity (DIO) and to healthy human subjects (n = 16) in a 75 g oral glucose tolerance test (OGTT) by a crossover design.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>In DIO mice, LPZ significantly improve glucose metabolism, increase plasma C-peptide and insulin compared with vehicle treatment. Furthermore, the combination of LPZ and SITA improved glucose tolerance additively, with higher plasma insulin and C-peptide levels compared with SITA-treated mice. Similarly, in human in the OGTT, the combination showed significant improvement in glucose-lowering and insulin increase vs SITA-treated group. However, no significant differences in area under curve (AUC) of insulin, glucose and C-peptide between the LPZ-treated group and baseline, except that mean AUCgastrin was significantly increased by LPZ.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>LPZ and SITA combination therapy appears to have complementary mechanisms of action and additive antidiabetic effect.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.12237","type":"journal-article","created":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T02:46:55Z","timestamp":1394765215000},"page":"1133-1139","source":"Crossref","is-referenced-by-count":7,"title":["Lansoprazole enhances the antidiabetic effect of sitagliptin in mice with diet-induced obesity and healthy human subjects"],"prefix":"10.1093","volume":"66","author":[{"given":"ShaoJun","family":"Hao","sequence":"first","affiliation":[{"name":"Department of Pharmacy and Equipment, No. 371 Hospital of PLA , Xin'xiang,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JianHua","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Equipment, No. 371 Hospital of PLA , Xin'xiang,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XiKui","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Cardiology, No. 371 Hospital of PLA , Xin'xiang,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Sun","sequence":"additional","affiliation":[{"name":"Institute of Drug and Instrument Control, Ji'nan Military Area , Ji'nan,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZhenXing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Drug and Instrument Control, Ji'nan Military Area , Ji'nan,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Gao","sequence":"additional","affiliation":[{"name":"Institute of Drug and Instrument Control, Ji'nan Military Area , Ji'nan,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,8,1]]},"reference":[{"key":"2024103109151287500_jphp12237-cit-0001","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/414782a","article-title":"Global and societal implications of the diabetes epidemic","volume":"414","author":"Zimmet","year":"2001","journal-title":"Nature"},{"key":"2024103109151287500_jphp12237-cit-0002","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nrendo.2013.47","article-title":"Emerging combinatorial hormone therapies for the treatment of obesity and T2DM","volume":"9","author":"Sadry","year":"2013","journal-title":"Nat Rev 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