{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:39:12Z","timestamp":1787585952295,"version":"build-2736575974"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["81270512"],"award-info":[{"award-number":["81270512"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Priority Academic Program Development of Jiangsu Higher Education Institution"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Emerging evidence indicates that Wnt\/\u03b2-catenin pathway is linked to the fibrosis of different organs including liver fibrosis. \u03b2-Catenin promotes hepatic stellate cells (HSCs) activation, a key event in the development of liver fibrosis, and has emerged as a novel mediator of fibrosis. Curcumin, a natural active ingredient derived from turmeric, possesses an inhibitory effect on liver fibrosis. This study is aimed to examine whether curcumin affects \u03b2-catenin expression\/activity in HSCs and explores the underlying mechanisms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The researchers used Western blot, real-time PCR, transfection assay and electrophoretic mobility shift assay and employed cultured HSCs and rat model of liver injury.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>Results showed that curcumin could reduce \u03b2-catenin protein level in HSCs\u2005in vitro and in vivo. Both \u03b2-catenin transactivation activity and DNA-binding activity were suppressed by curcumin. Moreover, nuclear \u03b2-catenin protein level was decreased by curcumin treatment. Further experiments suggested that delta-like homologue 1 contributed to curcumin inhibition of \u03b2-catenin transactivation activity in cultured HSCs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Curcumin affects \u03b2-catenin pathway in HSCs and might suggest a possible new explanation for the effects of curcumin on HSC activation and liver fibrosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.12283","type":"journal-article","created":{"date-parts":[[2014,6,19]],"date-time":"2014-06-19T15:20:09Z","timestamp":1403191209000},"page":"1615-1622","source":"Crossref","is-referenced-by-count":24,"title":["Curcumin affects \u03b2-catenin pathway in hepatic stellate cell <i>in vitro<\/i> and <i>in vivo<\/i>"],"prefix":"10.1093","volume":"66","author":[{"given":"Lei","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Radiology, the Second Affiliated Hospital of Nantong University , Nantong, Jiangsu,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Medical College, Nantong University , Nantong, Jiangsu,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Medical College, Nantong University , Nantong, Jiangsu,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuguang","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Medical College, Nantong University , Nantong, Jiangsu,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of 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