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Toluidine blue staining were used to analyse the infiltration and the percentage degranulation MCs. Immunohistochemical analysis showed CD117, transforming growth factor beta 1 (TGF-\u03b21), matrix metalloproteinase 9 (MMP-9), the osteoclast markers cathepsin K and tartrate-resistant acid phosphatase (TRAP) protein expression in ankle tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key findings<\/jats:title><jats:p>We found that both infiltration and degranulation of MCs increased at 24 h after MSU injection in the ankle joint. Immunohistochemical analysis showed that MSU induced upregulation of TGF-\u03b21, MMP-9, the osteoclast markers cathepsin K and TRAP in ankle tissues. Administration of lemnalol ameliorated MSU-induced TGF-\u03b21, MMP-9, cathepsin K and TRAP protein expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Taken together, our results show that MSU-induced gouty arthritis is accompanied by osteoclast-related protein upregulation and that lemnalol treatment may be beneficial for the attenuation of MC infiltration and degranulation and for suppressing osteoclast activation in gouty arthritis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jphp.12331","type":"journal-article","created":{"date-parts":[[2014,12,31]],"date-time":"2014-12-31T07:07:19Z","timestamp":1420009639000},"page":"274-285","source":"Crossref","is-referenced-by-count":18,"title":["Lemnalol attenuates mast cell activation and osteoclast activity in a gouty arthritis model"],"prefix":"10.1093","volume":"67","author":[{"given":"Hsin-Pai","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University , Kaohsiung,","place":["Taiwan"]},{"name":"Department of Orthopaedic Surgery, Ping-Tung Christian Hospital , Ping-Tung,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen-You","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University , Kaohsiung,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Yih","family":"Duh","sequence":"additional","affiliation":[{"name":"Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University , Kaohsiung,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Ying","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University , Kaohsiung,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Fragrance and Cosmetic Science, Center of Excellence for Environmental Medicine, Kaohsiung Medical University , Kaohsiung,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Fen","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Life Science, Institute of Molecular Biology, National Chung-Cheng University , Chia-Yi,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Chun","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Ping-Tung Christian Hospital , Ping-Tung,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen-Hsuan","family":"Jean","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Ping-Tung Christian Hospital , Ping-Tung,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Hong","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University , Kaohsiung,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,2,1]]},"reference":[{"key":"2024103012492862000_jphp12331-cit-0001","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1056\/NEJMcp1001124","article-title":"Clinical practice. 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