{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:53:34Z","timestamp":1788872014147,"version":"build-2803163510"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:00:00Z","timestamp":1612915200000},"content-version":"vor","delay-in-days":2142,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Capes","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Z eyheria montana is a medicinal plant used in Brazilian folk medicine for treating skin affections, ulcers, inflammation and diarrhoea, and as an antisyphilitic and antiblenorrhagic agent, but little is known about its mechanisms of action. Herein, a bio-guided assay was carried out to further evaluate its antioxidant and immunomodulatory effects, and the possible benefits on experimental intestinal inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Extracts, partitions, fractions and isolated compounds were tested for inhibition of lipid peroxidation. Isolated compounds were tested in vitro for its antioxidant and immunomodulatory action prior to in-vivo evaluation in trinitrobenzenesulfonic acid-induced rat colitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>Two major compounds were identified in the leaf dichloromethane extract: 3\u2032-hydroxy-5,7,4\u2032-trimethoxyflavone and 6-hydroxy-5,7-dimethoxyflavone, which exhibited an antioxidant activity. The compounds protected the colonic glutathione levels in more than 90% despite the absence of protection against the gross macroscopic colonic damage. In addition, the compounds inhibited IL-1\u00df secretion by macrophages in 91.5% and 72.7% respectively, whereas both reduced IL-6 secretion in about 44.5%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The major active compounds from Z. montana leaves exerted antioxidant and immunomodulatory effects, endorsing the use of Z. montana in folk medicine as an anti-inflammatory agent. However, further investigation is still needed regarding medicinal plants and the identification of candidate compounds for the treatment of the inflammatory bowel diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jphp.12354","type":"journal-article","created":{"date-parts":[[2014,12,31]],"date-time":"2014-12-31T02:59:15Z","timestamp":1419994755000},"page":"597-604","source":"Crossref","is-referenced-by-count":6,"title":["<i>Z<\/i>\n                    <i>eyheria montana<\/i>\n                    \u2005Mart. (Bignoniaceae) as source of antioxidant and immunomodulatory compounds with beneficial effects on intestinal inflammation"],"prefix":"10.1093","volume":"67","author":[{"given":"Leonardo Noboru","family":"Seito","sequence":"first","affiliation":[{"name":"Laboratory of Phytomedicines, Pharmacology and Biotechnology (PhytoPharmaTech), Department of Pharmacology, Biosciences Institute, UNESP \u2013 Univ Estadual Paulista , Botucatu, SP,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Maur\u00edcio","family":"Sforcin","sequence":"additional","affiliation":[{"name":"Laboratory of Immunomodulation by Natural Products, Department of Microbiology and Immunology, Biosciences Institute, UNESP \u2013 Univ Estadual Paulista , Botucatu, SP,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jairo Kenupp","family":"Bastos","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacognosy, Faculty of Pharmaceutical Sciences, USP \u2013 Universidade de S\u00e3o Paulo , Ribeir\u00e3o Preto, SP,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Claudio","family":"Di Stasi","sequence":"additional","affiliation":[{"name":"Laboratory of Phytomedicines, Pharmacology and Biotechnology (PhytoPharmaTech), Department of Pharmacology, Biosciences Institute, UNESP \u2013 Univ Estadual Paulista , Botucatu, SP,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,4,1]]},"reference":[{"key":"2026041420232954400_jphp12354-cit-0001","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/00001574-199907000-00003","article-title":"Pathogenesis of inflammatory bowel disease","volume":"15","author":"Katz","year":"1999","journal-title":"Curr Opin Gastroenterol"},{"key":"2026041420232954400_jphp12354-cit-0002","doi-asserted-by":"crossref","first-page":"387","DOI":"10.2174\/1389450003349056","article-title":"The ubiquitin-dependent proteolytic system and other potential targets for the modulation of nuclear factor-kB (NF-kB)","volume":"1","author":"Magnani","year":"2000","journal-title":"Curr Drug Targets"},{"key":"2026041420232954400_jphp12354-cit-0003","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/path.1408","article-title":"Imbalanced secondary mucosal antioxidant response in inflammatory bowel disease","volume":"201","author":"Kruidenier","year":"2003","journal-title":"J Pathol"},{"key":"2026041420232954400_jphp12354-cit-0004","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/0016-5085(90)90329-Y","article-title":"Clinical evidence supporting the radical scavenger mechanism of 5-aminosalicylic acid","volume":"98","author":"Ahnfelt-Ronne","year":"1990","journal-title":"Gastroenterology"},{"key":"2026041420232954400_jphp12354-cit-0005","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S0140-6736(94)92831-2","article-title":"Oxidants and free radicals in inflammatory bowel disease","volume":"344","author":"Grisham","year":"1994","journal-title":"Lancet"},{"key":"2026041420232954400_jphp12354-cit-0006","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.1097\/00054725-200810001-00057","article-title":"What is the role of cytokines and chemokines in IBD?","volume":"14","author":"Fina","year":"2008","journal-title":"Inflamm Bowel Dis"},{"key":"2026041420232954400_jphp12354-cit-0007","first-page":"607","article-title":"Effects of flavonoids on gastrointestinal disorders","volume-title":"Studies in Natural Products Chemistry","author":"G\u00e1lvez","year":"2001"},{"key":"2026041420232954400_jphp12354-cit-0008","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1024\/0300-9831.71.4.243","article-title":"Dietary vitamin E supplementation protects the rat large intestine from experimental inflammation","volume":"71","author":"Gonz\u00e1les","year":"2001","journal-title":"Int J Vitam Nutr Res"},{"key":"2026041420232954400_jphp12354-cit-0009","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0014-2999(00)00623-3","article-title":"Tempol, a membrane permeable radical scavenger, reduces dinitrobenzene sulfonic acid-induced colitis","volume":"406","author":"Cuzzocrea","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"2026041420232954400_jphp12354-cit-0010","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1055\/s-2004-818942","article-title":"Intestinal anti-inflammatory activity of paepalantine, an isocoumarin isolated from the capitula of Paepalanthus bromelioides, in the trinitrobenzenesulphonic acid model of rat colitis","volume":"70","author":"Di Stasi","year":"2004","journal-title":"Planta Med"},{"key":"2026041420232954400_jphp12354-cit-0011","article-title":"Epicatechin used in the treatment of intestinal inflammatory disease: an analysis by experimental models","author":"Vasconcelos","journal-title":"Evid Based Complement Alternat Med"},{"key":"2026041420232954400_jphp12354-cit-0012","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1248\/bpb.31.1343","article-title":"Intestinal anti-inflammatory activity of coumarin and 4-hydroxycoumarin in the trinitrobenzenesulphonic acid model of rat colitis","volume":"31","author":"Luchini","year":"2008","journal-title":"Biol Pharm Bull"},{"key":"2026041420232954400_jphp12354-cit-0013","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.cbi.2010.03.045","article-title":"Intestinal anti-inflammatory activity of esculetin and 4-methylesculetin in the trinitrobenzenesulphonic acid model of rat colitis","volume":"186","author":"Witaicenis","year":"2010","journal-title":"Chem Biol Interact"},{"key":"2026041420232954400_jphp12354-cit-0014","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cbi.2011.11.004","article-title":"Suppression of TNBS-induced colitis in rats by 4-methylesculetin, a natural coumarin: comparison with prednisolone and sulphasalazine","volume":"195","author":"Witaicenis","year":"2012","journal-title":"Chem Biol Interact"},{"key":"2026041420232954400_jphp12354-cit-0015","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.phymed.2013.09.001","article-title":"Antioxidant and intestinal anti-inflammatory effects of plant-derived coumarin derivatives","volume":"21","author":"Witaicenis","year":"2014","journal-title":"Phytomedicine"},{"key":"2026041420232954400_jphp12354-cit-0016","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1590\/S0074-02762008000800004","article-title":"Anti-inflammatory and anti-nociceptive effects of Zeyheria montana (Bignoniaceae) ethanol extract","volume":"103","author":"Guenka","year":"2008","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"2026041420232954400_jphp12354-cit-0017","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/0021-9673(95)00841-1","article-title":"High-performance liquid chromatographic separation of some naturally occurring naphthoquinones and anthraquinones","volume":"723","author":"Steinert","year":"1996","journal-title":"J Chromatogr A"},{"key":"2026041420232954400_jphp12354-cit-0018","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1590\/S0102-695X2001000100002","article-title":"Estudo qu\u00edmico de Zeyheria montana M. (bolsa-de-pastor)","volume":"11","author":"J\u00e1come","year":"2001","journal-title":"Rev Bras Farmacogn"},{"key":"2026041420232954400_jphp12354-cit-0019","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/aob\/mcj042","article-title":"Ovary peltate trichomes of Zeyheria montana (Bignoniaceae): developmental ultrastructure and secretion in relation to function","volume":"97","author":"Machado","year":"2006","journal-title":"Ann Bot"},{"key":"2026041420232954400_jphp12354-cit-0020","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1002\/ptr.3438","article-title":"Antiproliferative activity of three methoxylated flavonoids isolated from Zeyheria montana Mart. (Bignoniaceae) leaves","volume":"25","author":"Seito","year":"2011","journal-title":"Phytother Res"},{"key":"2026041420232954400_jphp12354-cit-0021","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1159\/000139325","article-title":"Flavonoid inhibition of enzymic and nonenzymic lipid peroxidation in rat liver differs from its influence on the glutathione-related enzymes","volume":"51","author":"G\u00e1lvez","year":"1995","journal-title":"Pharmacology"},{"key":"2026041420232954400_jphp12354-cit-0022","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0016-5085(89)80079-4","article-title":"Hapten-induced model of chronic inflammation and ulceration in the rat colon","volume":"96","author":"Morris","year":"1989","journal-title":"Gastroenterology"},{"key":"2026041420232954400_jphp12354-cit-0023","doi-asserted-by":"crossref","first-page":"G622","DOI":"10.1152\/ajpgi.1995.268.4.G622","article-title":"Disruption of colonic electrolyte transport in experimental colitis","volume":"268","author":"Bell","year":"1995","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2026041420232954400_jphp12354-cit-0024","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/0016-5085(84)90202-6","article-title":"Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity","volume":"84","author":"Krawisz","year":"1984","journal-title":"Gastroenterology"},{"key":"2026041420232954400_jphp12354-cit-0025","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0021-9258(18)43072-4","article-title":"Method for rapid determination of alkaline phosphatase","volume":"164","author":"Bessey","year":"1946","journal-title":"J Biol Chem"},{"key":"2026041420232954400_jphp12354-cit-0026","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/S0076-6879(85)13073-9","article-title":"Determination of glutathione and glutathione disulfide in biological samples","volume":"113","author":"Anderson","year":"1985","journal-title":"Methods Enzymol"},{"key":"2026041420232954400_jphp12354-cit-0027","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1590\/S0104-79302000000200006","article-title":"Immunomodulatory action of propolis on macrophage activation","volume":"6","author":"Orsi","year":"2000","journal-title":"J Venom Anim Toxins"},{"key":"2026041420232954400_jphp12354-cit-0028","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2407-6-227","article-title":"Quantification of Epstein-Barr virus DNA load, interleukin-6, interleukin-10, transforming growth factor-(1 and stem cell factor in plasma of patients with nasopharyngeal carcinoma","volume":"6","author":"Tan","year":"2006","journal-title":"BMC Cancer"},{"key":"2026041420232954400_jphp12354-cit-0029","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1039\/JR9530002764","article-title":"The flavonoid glycosides of Dahlia variabilis. Part I. General introduction. Cyanidin, apigenin, and luteolin glycosides from the variety Dandy","volume":"555","author":"Nordstr\u00f6m","year":"1953","journal-title":"J Chem Soc"},{"key":"2026041420232954400_jphp12354-cit-0030","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1080\/00397919908086038","article-title":"A novel route to 5,7-dimethoxy-6-hydroxyflavone","volume":"29","author":"Osorio-Olivares","year":"1999","journal-title":"Synth Commun"},{"key":"2026041420232954400_jphp12354-cit-0031","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2174\/0929867013373723","article-title":"Biological properties of citrus flavonoids pertaining to cancer and inflammation","volume":"8","author":"Manthey","year":"2001","journal-title":"Curr Med Chem"},{"key":"2026041420232954400_jphp12354-cit-0032","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.semcancer.2007.05.002","article-title":"Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?","volume":"17","author":"Walle","year":"2007","journal-title":"Semin Cancer Biol"},{"key":"2026041420232954400_jphp12354-cit-0033","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1136\/gut.2006.094599","article-title":"Polyphenols in the treatment of inflammatory bowel disease and pancreatitis","volume":"56","author":"Shapiro","year":"2007","journal-title":"Gut"},{"key":"2026041420232954400_jphp12354-cit-0034","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.2174\/1381612043382710","article-title":"Natural and synthetic coumarin derivatives with anti-inflammatory\/antioxidant activities","volume":"10","author":"Fylaktakidou","year":"2004","journal-title":"Curr Pharm Des"},{"key":"2026041420232954400_jphp12354-cit-0035","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.bcp.2006.07.016","article-title":"Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: analysis of the structure\u2013activity relationship","volume":"72","author":"Comalada","year":"2006","journal-title":"Biochem Pharmacol"},{"key":"2026041420232954400_jphp12354-cit-0036","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2007.05.012","article-title":"Propolis and the immune system: a review","volume":"113","author":"Sforcin","year":"2007","journal-title":"J Ethnopharmacol"},{"key":"2026041420232954400_jphp12354-cit-0037","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S0022-3565(25)20662-0","article-title":"Effect of quercitrin on acute and chronic experimental colitis in the rat","volume":"278","author":"S\u00e1nchez de Medina","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"key":"2026041420232954400_jphp12354-cit-0038","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1055\/s-2006-957723","article-title":"Rutoside as mucosal protective in acetic acid-induced rat colitis","volume":"63","author":"G\u00e1lvez","year":"1997","journal-title":"Planta Med"},{"key":"2026041420232954400_jphp12354-cit-0039","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0024-3205(97)01164-8","article-title":"Oral administration of rutoside can ameliorate inflammatory bowel disease in rats","volume":"62","author":"Cruz","year":"1998","journal-title":"Life Sci"},{"key":"2026041420232954400_jphp12354-cit-0040","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1055\/s-2006-960838","article-title":"Antiinflammatory activity of diosmin and hesperidin in rat colitis induced by TNBS","volume":"65","author":"Crespo","year":"1999","journal-title":"Planta Med"},{"key":"2026041420232954400_jphp12354-cit-0041","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1016\/S0024-3205(02)01568-0","article-title":"Effect of quercitrin on the early stages of hapten induced colonic inflammation in the rat","volume":"70","author":"S\u00e1nchez de Medina","year":"2002","journal-title":"Life Sci"},{"key":"2026041420232954400_jphp12354-cit-0042","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.bcp.2004.10.015","article-title":"Dietary rutin, but not its aglycone quercetin, ameliorates dextran sulfate sodium-induced experimental colitis in mice: attenuation of pro-inflammatory gene expression","volume":"69","author":"Kwon","year":"2005","journal-title":"Biochem Pharmacol"},{"key":"2026041420232954400_jphp12354-cit-0043","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1002\/eji.200425778","article-title":"In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-\u03baB pathway","volume":"35","author":"Comalada","year":"2005","journal-title":"Eur J Immunol"},{"key":"2026041420232954400_jphp12354-cit-0044","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/ptr.1611","article-title":"Therapeutic efficacy of pycnogenol in experimental inflammatory bowel diseases","volume":"18","author":"Mochizuki","year":"2004","journal-title":"Phytother Res"},{"key":"2026041420232954400_jphp12354-cit-0045","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/sj.bjp.0706847","article-title":"Protection from experimental colitis by theaflavin-3,30-digallate correlates with inhibition of IKK and NF-kappa B activation","volume":"149","author":"Ukil","year":"2006","journal-title":"Br J Pharmacol"},{"key":"2026041420232954400_jphp12354-cit-0046","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1007\/s11095-005-6250-z","article-title":"Metabolic and pharmacological properties of rutin, a quercetin dietary glycoside, for treatment of inflammatory bowel disease","volume":"22","author":"Kim","year":"2005","journal-title":"Pharm Res"},{"key":"2026041420232954400_jphp12354-cit-0047","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/0016-5085(92)91710-L","article-title":"A comparative analysis of two models of colitis in rats","volume":"102","author":"Yamada","year":"1992","journal-title":"Gastroenterology"},{"key":"2026041420232954400_jphp12354-cit-0048","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0014-2999(02)02949-7","article-title":"Effects of dosmalfate, a new cytoprotective agent, on acute and chronic trinitrobenzene sulphonic acid-induced colitis in rats","volume":"460","author":"Villegas","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"2026041420232954400_jphp12354-cit-0049","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0022-3565(25)24349-X","article-title":"BPC-15 reduced trinitrobenzene sulfonic acid-induced colonic damage in rats","volume":"272","author":"Veljaca","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"2026041420232954400_jphp12354-cit-0050","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/S0016-5085(88)80015-5","article-title":"Immunohistologic study of ulcerative colitis with monoclonal antibodies against tumor-associated and\/or differentiation antigens","volume":"95","author":"Cooper","year":"1988","journal-title":"Gastroenterology"},{"key":"2026041420232954400_jphp12354-cit-0051","first-page":"3299","article-title":"The Cap\u2018n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45- related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes","volume":"61","author":"McMahon","year":"2001","journal-title":"Cancer Res"},{"key":"2026041420232954400_jphp12354-cit-0052","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.trsl.2006.11.009","article-title":"Immune dysfunction in inflammatory bowel disease","volume":"149","author":"Neuman","year":"2007","journal-title":"Transl Res"},{"key":"2026041420232954400_jphp12354-cit-0053","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1365-2796.2008.01953.x","article-title":"NF-\u03baB in inflammatory bowel disease","volume":"263","author":"Atreya","year":"2008","journal-title":"J Intern Med"},{"key":"2026041420232954400_jphp12354-cit-0054","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1136\/gut.43.6.856","article-title":"Role of NF-\u03baB in immune and inflammatory responses in the gut","volume":"43","author":"Neurath","year":"1998","journal-title":"Gut"},{"key":"2026041420232954400_jphp12354-cit-0055","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.bcp.2008.06.001","article-title":"Effect of flavonoids on rat splenocytes, a structure\u2013activity relationship study","volume":"76","author":"L\u00f3pez-Posadas","year":"2008","journal-title":"Biochem Pharmacol"},{"key":"2026041420232954400_jphp12354-cit-0056","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.freeradbiomed.2007.02.017","article-title":"Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin","volume":"42","author":"Tanigawa","year":"2007","journal-title":"Free Radic Biol Med"},{"key":"2026041420232954400_jphp12354-cit-0057","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1159\/000110446","article-title":"Epigallocatechin-3-O-gallate inhibits the angiotensin II-induced adhesion molecule expression in human umbilical vein endothelial cell via inhibition of MAPK pathways","volume":"20","author":"Chae","year":"2007","journal-title":"Cell Physiol Biochem"}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjphp.12354","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjphp.12354","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/67\/4\/597\/60227764\/jphp12354.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/67\/4\/597\/60227764\/jphp12354.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:45:55Z","timestamp":1776213955000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/67\/4\/597\/6128255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,1]]},"references-count":57,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jphp.12354","relation":{},"ISSN":["2042-7158","0022-3573"],"issn-type":[{"value":"2042-7158","type":"electronic"},{"value":"0022-3573","type":"print"}],"subject":[],"published-other":{"date-parts":[[2015,4]]},"published":{"date-parts":[[2015,4,1]]}}}