{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:10:21Z","timestamp":1791933021753,"version":"4.3.4"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Counsel of Technological and Scientific Development \u2013 CNPq"},{"name":"Research Foundation for the State of Piau\u00ed \u2013 FAPEPI"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of the study was to investigate the anti-inflammatory, antioxidant and antinociceptive actions of PFPe, a polysaccharide fraction isolated from the dried fruit of the Passiflora edulis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Animals were pretreated with PFPe (0.3, 1 or 3 mg\/kg, i.p.) 1 h before induction of paw oedema by carrageenan, histamine, serotonin, compound 48\/80 or prostaglandin E2 (PGE2). Neutrophil migration and vascular permeability were measured after carrageenan injection into the peritoneum, and the action of the PFPe on the tumour necrosis factor-alpha, interleukin-1 beta (IL-1\u03b2), myeloperoxidase (MPO), glutathione (GSH) and malondialdehyde (MDA) levels was also evaluated. To assay nociception, we examined acetic acid-induced writhing, formalin-induced paw licking and response latency in the hot plate test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>Pretreatment with PFPe significantly inhibited carrageenan-induced paw oedema. PFPe also reduced paw oedema induced by compound 48\/80, histamine, serotonin, and PGE2 and compound 48\/80-induced vascular permeability. In addition, PFPe significantly reduced the MPO activity, MDA and GSH concentrations, and IL-1\u03b2 level. In the nociception tests, PFPe reduced acetic acid-induced writhing and formalin-induced paw licking and did not increase the response latency time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results suggest that PFPe administration reduces the inflammatory response by modulation of the liberation or synthesis of histamine and serotonin, by reduction of neutrophil migration, IL-1\u03b2 levels, and oxidative stress and nociception.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jphp.12399","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T17:32:52Z","timestamp":1427218372000},"page":"1017-1027","source":"Crossref","is-referenced-by-count":47,"title":["Polysaccharide fraction isolated from\n                    <i>P<\/i>\n                    <i>assiflora edulis<\/i>\n                    inhibits the inflammatory response and the oxidative stress in mice"],"prefix":"10.1093","volume":"67","author":[{"given":"Renan O","family":"Silva","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacology of Inflammation and Cancer, Department of Physiology and Pharmacology, Federal University of Cear\u00e1 , Fortaleza, Cear\u00e1,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samara R B","family":"Damasceno","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology of Inflammation and Cancer, Department of Physiology and Pharmacology, Federal University of Cear\u00e1 , Fortaleza, Cear\u00e1,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarc\u00edsio V","family":"Brito","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Physiopharmacology, Biotechnology and Biodiversity Center Research (BIOTEC), Federal University of Piau\u00ed , Parna\u00edba, Piau\u00ed,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordana M","family":"Dias","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Physiopharmacology, Biotechnology and Biodiversity Center Research (BIOTEC), Federal University of Piau\u00ed , Parna\u00edba, Piau\u00ed,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda M","family":"Fontenele","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Physiopharmacology, Biotechnology and Biodiversity Center Research (BIOTEC), Federal University of Piau\u00ed , Parna\u00edba, Piau\u00ed,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela S","family":"Bra\u00fana","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Physiopharmacology, Biotechnology and Biodiversity Center Research (BIOTEC), Federal University of Piau\u00ed , Parna\u00edba, Piau\u00ed,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 S C","family":"J\u00fanior","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Physiopharmacology, Biotechnology and Biodiversity Center Research (BIOTEC), Federal University of Piau\u00ed , Parna\u00edba, Piau\u00ed,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanny S","family":"Maciel","sequence":"additional","affiliation":[{"name":"Laboratory of Polymer, Department of Organic and Inorganic Chemistry, Federal University of Cear\u00e1 , Fortaleza, Cear\u00e1,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina C M","family":"de Paula","sequence":"additional","affiliation":[{"name":"Laboratory of Polymer, Department of Organic and Inorganic Chemistry, Federal University of Cear\u00e1 , Fortaleza, Cear\u00e1,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronaldo A","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology of Inflammation and Cancer, Department of Physiology and Pharmacology, Federal University of Cear\u00e1 , Fortaleza, Cear\u00e1,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcellus H L P","family":"Souza","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology of Inflammation and Cancer, Department of Physiology and Pharmacology, Federal University of Cear\u00e1 , Fortaleza, Cear\u00e1,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L P","family":"Freitas","sequence":"additional","affiliation":[{"name":"Laboratory of Proteins and Carbohydrates of Marine Algae, Department of Biochemistry and Molecular Biology, Federal University of Cear\u00e1 , Fortaleza, 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