{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T04:31:48Z","timestamp":1730349108476,"version":"3.28.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Youth Fund of National Natural Science Fund","award":["81100813"],"award-info":[{"award-number":["81100813"]}]},{"name":"Natural Science Fund for Colleges and Universities in Jiangsu Province","award":["11KJB320018"],"award-info":[{"award-number":["11KJB320018"]}]},{"name":"A Project of Shandong Province Higher Educational Science and Technology Program","award":["J14LL02"],"award-info":[{"award-number":["J14LL02"]}]},{"name":"Youth Fund of the Affiliated Hospital of Binzhou Medical University","award":["2013QNKYJJ09"],"award-info":[{"award-number":["2013QNKYJJ09"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We investigated the analgesic effects of lidocaine (LDC) and lidocane derivative, QX-572, co-application on the evoked pain behaviour (complete Freund's Adjuvant (CFA)-induced) and spontaneous pain behaviour (formalin-induced) in mice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The experiments were performed using adult male Kunming mice. Formalin-induced acute pain model and CFA-induced chronic pain model was established by injecting formalin and CFA, respectively. Separate injections of LDC and QX-572, or co-injection of LDC and QX-572, were performed to observe the differences in neurobehavioural responses, paw withdrawal latency (PWL) and mechanical withdrawal threshold (MWT).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>QX-572 injection alone did not influence PWL and MWT, but injection of LDC alone led to a substantial, but short-lived, elevation in PWL and MWT (45 min). Co-injection of LDC and QX-572, however, resulted in a significant increase in PWL and MWT (120 min) compared with the LDC group. Injection of LDC and QX-572 combination in the adjacent sciatic nerve also produced a long-lasting sensory-specific nerve block. Additionally, intraplantar co-injection of LDC and QX-572 combination inhibited spontaneous pain in formalin-treated mice, but did not detectably attenuated hyperalgesia and allodynia in CFA-treated mice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our results provide evidence that QX-572 induced sensory-selective blockade and co-injection of QX-572 and LDC enhance pain blockade, as evident from formalin-treated mice.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.12419","type":"journal-article","created":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T07:06:57Z","timestamp":1429772817000},"page":"1272-1278","source":"Crossref","is-referenced-by-count":5,"title":["Co-application of lidocaine and QX-572 induces divergent pain behaviours in mice"],"prefix":"10.1093","volume":"67","author":[{"given":"Cui-Jie","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Pain, The Affiliated Hospital of Binzhou Medical College , Binzhou, Shandong,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pain, The Affiliated Hospital of Binzhou Medical College , Binzhou, Shandong,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhao","sequence":"additional","affiliation":[{"name":"The People's Hospital of Binzhou , Binzhou, Shandong,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Pain, The Affiliated Hospital of Binzhou Medical College , Binzhou, Shandong,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pain, The Affiliated Hospital of Binzhou Medical College , Binzhou, Shandong,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De-Qiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pain, The Affiliated Hospital of Binzhou Medical College , Binzhou, Shandong,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,9,1]]},"reference":[{"key":"2024103012484944900_jphp12419-cit-0001","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1016\/j.pain.2011.04.020","article-title":"Contribution of afferent pathways to nerve injury-induced spontaneous pain and evoked 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