{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T18:45:27Z","timestamp":1763837127169,"version":"3.37.3"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100008305","name":"Western New England University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008305","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This study aims to examine the potential of radiomimetic compounds as antimicrobial therapeutics, as the recent advances in radiomimetic targeting as well as rapid increase of multidrug resistant bacteria make these compounds attractive for future development.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Representative radiomimetics from each of the three major categories was examined; C-1027 and neocarzinostatin from the protein-chromophore enediyne family; Calicheamicin from the non-protein chromophore enediyne family and Bleomycin and Tallysomycin S10b from the glycopeptide family. The activity of these compounds was examined against 12 distinct bacteria species. Inhibition was determined using disc diffusion assays and a subsequent examination of minimum inhibitory concentration of a representative organism. The onset of action of the compounds was also determined by incubating the organisms with drug in liquid media, before plating, and then determining if growth occurred.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We found that the radiomimetic glycopeptides were more active against Gram-negative species, while the enediynes were more effective against Gram-positive species. The radiomimetics also maintained their rapid onset of action, working as quickly as 5 min.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Radiomimetic compounds have activity against a wide variety of microorganisms and would support the development of radiomimetic\u2013antibody conjugates as potential antibiotics as an option against severe bacterial infections.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.12432","type":"journal-article","created":{"date-parts":[[2015,4,29]],"date-time":"2015-04-29T11:51:41Z","timestamp":1430308301000},"page":"1371-1379","source":"Crossref","is-referenced-by-count":7,"title":["A novel application of radiomimetic compounds as antibiotic drugs"],"prefix":"10.1093","volume":"67","author":[{"given":"Christina C","family":"Andros","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical and Administrative Sciences, College of Pharmacy , Springfield, MA,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan A","family":"Dubay","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Administrative Sciences, College of Pharmacy , Springfield, MA,","place":["USA"]},{"name":"Department of Natural Sciences, College of Arts and Sciences, Western New England University , Springfield, MA,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayleigh D","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Administrative Sciences, College of Pharmacy , Springfield, MA,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Natural Sciences, College of Arts and Sciences, Western New England University , Springfield, MA,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawn E","family":"Holmes","sequence":"additional","affiliation":[{"name":"Department of Natural Sciences, College of Arts and Sciences, Western New England University , Springfield, MA,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel R","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Administrative Sciences, College of Pharmacy , Springfield, MA,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,10,1]]},"reference":[{"volume-title":"The Bacterial Challenge, Time to React: A Call to Narrow the Gap between Multidrug-Resistant Bacteria in the EU and the Development of New Antibacterial Agents: ECDC","year":"2009","author":"European Centre for Disease Prevention Control","key":"2024103012491761500_jphp12432-cit-0001"},{"key":"2024103012491761500_jphp12432-cit-0002","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1086\/524891","article-title":"The epidemic of antibiotic-resistant infections: a call to action for the medical community from the Infectious Diseases Society of America","volume":"46","author":"Spellberg","year":"2008","journal-title":"Clin Infect Dis"},{"key":"2024103012491761500_jphp12432-cit-0003","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1093\/jac\/dkr260","article-title":"Discovery BWPoTUNRAD, Development. 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