{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T10:51:09Z","timestamp":1788000669043,"version":"build-2784847793"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We attempted to ascertain if bisbenzylisoquinoline alkaloids, liensinine and isoliensinine from Nelumbo nucifera Gaertner have antidepressant-like effects and compare the effects with those previously obtained by their analogue neferine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using mice, the forced swimming test (FST) was carried out after treatment with liensinine, isoliensinine and neferine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key findings<\/jats:title><jats:p>Liensinine and isoliensinine elicited antidepressant-like effects in mice after the FST. Anti-immobility effects of liensinine and isoliensinine were antagonized by the 5-hydroxytryptamine1A (5-HT1A) receptor antagonist WAY 100635, but not by the \u03b11-adrenoceptor antagonist prazosin. The anti-immobility effects of liensinine, isoliensinine and neferine were blocked by pretreatment with p-chlorophenylalanine (PCPA), which depletes serotonin (5-HT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data suggest that liensinine and isoliensinine from Nelumbo nucifera Gaertner have antidepressant-like effects and that antidepressant-like effects of liensinine and its analogues are closely related to serotonergic mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jphp.12473","type":"journal-article","created":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T03:02:08Z","timestamp":1438830128000},"page":"1716-1722","source":"Crossref","is-referenced-by-count":28,"title":["Serotonergic mechanisms are involved in antidepressant-like effects of bisbenzylisoquinolines liensinine and its analogs isolated from the embryo of<i>Nelumbo nucifera<\/i>Gaertner seeds in mice"],"prefix":"10.1093","volume":"67","author":[{"given":"Yumi","family":"Sugimoto","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Yasuda Women\u2019s University , Hiroshima,","place":["Japan"]},{"name":"Department of Organic Chemistry, Kobe Pharmaceutical University , Kobe,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsumi","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Kobe Pharmaceutical University , Kobe,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuko","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Kobe Pharmaceutical University , Kobe,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Tanahashi","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Kobe Pharmaceutical University , Kobe,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Research Center for Industry Innovation, Osaka City University , Osaka,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Oshiro","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine , Osaka,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujian","family":"Sun","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine , Osaka,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Toda","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Department of Clinical Pharmacy, Yokohama College of Pharmacy , Yokohama,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yamada","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Department of Clinical Pharmacy, Yokohama College of Pharmacy , Yokohama,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,12,1]]},"reference":[{"key":"2024103012541385300_jphp12473-cit-0001","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.euroneuro.2011.04.002","article-title":"Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence","volume":"21","author":"Sarris","year":"2011","journal-title":"Eur Neuropsychopharmacol"},{"key":"2024103012541385300_jphp12473-cit-0002","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1211\/jpp\/61.04.0001","article-title":"The sacred lotus (Nelumbo nucifera) \u2013 phytochemical and therapeutic profile","volume":"61","author":"Mukherjee","year":"2009","journal-title":"J Pharm Pharmacol"},{"key":"2024103012541385300_jphp12473-cit-0003","article-title":"Zhong-yao-dai-ci-dian (Dictionary of Chinese Crude Drugs)","author":"Chiangsu Medical College","year":"1978"},{"key":"2024103012541385300_jphp12473-cit-0004","first-page":"215","article-title":"Studies on the alkaloids of embryo loti, Nelumbo nucifera Gaertn. 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