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We also measured the superoxide anion (O2\u2212) and hydrogen peroxide (H2O2) generation, superoxide dismutase (SOD) and catalase activity and \u03b1-actin expression in rat corpus cavernosum from both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>HHcy increased PE-induced contraction in cavernosal strips. Tiron, PEG-catalase or tempol increased PE-induced contraction in strips from control rats, but it was not altered by tiron or PEG-catalase in HHcy rats, whereas tempol reduced this response. The combination of PEG-catalase and tempol did not alter the contractile response to PE in both groups. HHcy increased O2\u2212 generation and SOD activity, whereas H2O2 concentration was reduced. Finally, HHcy did not alter catalase activity or expression of \u03b1-actin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The major new finding from this study is that HHcy induced a marked increase in PE-induced contraction in rat corpus cavernosum by a mechanism that involves increased O2\u2212 generation and it could play a role in the pathogenesis of erectile dysfunction associated with HHcy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jphp.12486","type":"journal-article","created":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T05:12:58Z","timestamp":1451884378000},"page":"63-75","source":"Crossref","is-referenced-by-count":8,"title":["Consequence of hyperhomocysteinaemia on \u03b11-adrenoceptor-mediated contraction in the rat corpus cavernosum: the role of reactive oxygen species"],"prefix":"10.1093","volume":"68","author":[{"given":"Hariane","family":"C\u00f4co","sequence":"first","affiliation":[{"name":"Departament of Pharmacology, Faculdade de Medicina de Ribeir\u00e3o Preto , Ribeir\u00e3o Preto, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa","family":"Pernomian","sequence":"additional","affiliation":[{"name":"Laboratory of Vascular Injury, Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto , Ribeir\u00e3o Preto, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katia C","family":"Marchi","sequence":"additional","affiliation":[{"name":"Departament of Pharmacology, Faculdade de Medicina de Ribeir\u00e3o Preto , Ribeir\u00e3o Preto, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayara S","family":"Gomes","sequence":"additional","affiliation":[{"name":"Laboratory of Vascular Injury, Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto , Ribeir\u00e3o Preto, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia R","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Department of Pathology and Legal Medicine, Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo , Ribeir\u00e3o Preto, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandra N Z","family":"Ramalho","sequence":"additional","affiliation":[{"name":"Nucleus of Applied Bioprospection and Molecular Research, Faculdades Inta , Fortaleza, CE,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos R","family":"Tirapelli","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Escola de Enfermagem de Ribeir\u00e3o Preto , Ribeir\u00e3o Preto, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana M","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Vascular Injury, Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto , Ribeir\u00e3o Preto, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,1,1]]},"reference":[{"key":"2026041420232850800_jphp12486-cit-0001","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0369-8114(03)00104-4","article-title":"Hyperhomocysteinemia: an independent risk factor or a simple marker of vascular disease? 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