{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:31:54Z","timestamp":1777627914492,"version":"3.51.4"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Czech Science Foundation","doi-asserted-by":"publisher","award":["P303\/120850"],"award-info":[{"award-number":["P303\/120850"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences, Inc.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Tenofovir and emtricitabine are very effective and well-tolerated antiretrovirals representing current backbone of the antiretroviral combination regimens for the prevention of perinatal HIV transmission. The aim of our study was to determine whether tenofovir or emtricitabine administered in long-term fashion affect expression of two widely described pharmacokinetic determinants, P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2), in maternal or fetal biological tissues.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>For this purpose, pregnant Wistar rats were administered tenofovir (2.25 mg\/kg\/day), emtricitabine (3.5 mg\/kg\/day) or saline i.m. for 10 days (from the 12th to 21st gestation day). On the 22nd day, the placenta and maternal\/fetal intestine, brain, kidneys and liver were sampled and analysed for Abcb1a, Abcb1b and Abcg2 expression; placental and newborns' weights were also monitored.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>We found that long-term application of tenofovir or emtricitabine did not significantly affect expression of Abcb1a, Abcb1b and Abcg2 in either maternal or fetal organs. However, tenofovir administration significantly increased placenta-to-birthweight ratio, a strong indicator of various diseases occurring later in life.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our data broaden current knowledge on safety profile of tenofovir and emtricitabine use in pregnancy. Nevertheless, further research in other mammal species, including humans, is important to fully elucidate this issue.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.12495","type":"journal-article","created":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T23:45:51Z","timestamp":1451951151000},"page":"84-92","source":"Crossref","is-referenced-by-count":7,"title":["Long-term administration of tenofovir or emtricitabine to pregnant rats; effect on <i>Abcb1a<\/i>, <i>Abcb1b<\/i> and <i>Abcg2<\/i> expression in the placenta and in maternal and fetal organs"],"prefix":"10.1093","volume":"68","author":[{"given":"Lukas","family":"Cerveny","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague , Hradec Kralove,","place":["Czech Republic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuzana","family":"Neumanova","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague , Hradec Kralove,","place":["Czech Republic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Karbanova","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague , Hradec Kralove,","place":["Czech Republic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Havlova","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague , Hradec Kralove,","place":["Czech Republic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frantisek","family":"Staud","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague , Hradec Kralove,","place":["Czech Republic"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,1,1]]},"reference":[{"key":"2024103012570128600_jphp12495-cit-0001","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1177\/1545109709343966","article-title":"First HAART in HIV-infected patients with high viral load: value of HIV RNA levels at 12 weeks to predict virologic outcome","volume":"8","author":"Townsend","year":"2009","journal-title":"J Int Assoc Physicians AIDS Care (Chic)"},{"key":"2024103012570128600_jphp12495-cit-0002","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1086\/650005","article-title":"Factors associated with mother-to-child transmission of HIV-1 despite a maternal viral load &lt;500 copies\/ml at delivery: a case-control study nested in the French perinatal cohort (EPF-ANRS CO1)","volume":"50","author":"Tubiana","year":"2010","journal-title":"Clin Infect Dis"},{"key":"2024103012570128600_jphp12495-cit-0003","volume-title":"Panel on Treatment of HIV-Infected Pregnant Women and Prevention of Perinatal Transmission. Recommendations for Use of Antiretroviral Drugs in Pregnant HIV-1-Infected Women for Maternal Health and Interventions to Reduce Perinatal HIV Transmission in the United States","year":"2014"},{"key":"2024103012570128600_jphp12495-cit-0004","volume-title":"Use of Antiretroviral Drugs for Treating Pregnant Women and Preventing HIV Infections in Infants","author":"WHO"},{"key":"2024103012570128600_jphp12495-cit-0005","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1097\/QAD.0b013e32835c208b","article-title":"The pharmacokinetics, safety and efficacy of tenofovir and emtricitabine in HIV-1-infected pregnant women","volume":"27","author":"Colbers","year":"2013","journal-title":"AIDS"},{"key":"2024103012570128600_jphp12495-cit-0006","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1097\/QAD.0b013e328352d135","article-title":"Safety of tenofovir use during pregnancy: early growth outcomes in HIV-exposed uninfected infants","volume":"26","author":"Siberry","year":"2012","journal-title":"AIDS"},{"key":"2024103012570128600_jphp12495-cit-0007","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1093\/jac\/dku483","article-title":"Tenofovir during pregnancy in rats: a novel pathway for programmed hypertension in the offspring","volume":"70","author":"Gois","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"2024103012570128600_jphp12495-cit-0008","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/00042560-200203010-00001","article-title":"Fetal and maternal outcome after administration of tenofovir to gravid rhesus monkeys (Macaca mulatta)","volume":"29","author":"Tarantal","year":"2002","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2024103012570128600_jphp12495-cit-0009","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.tips.2009.10.001","article-title":"The complexities of antiretroviral drug-drug interactions: role of ABC and SLC transporters","volume":"31","author":"Kis","year":"2010","journal-title":"Trends Pharmacol Sci"},{"key":"2024103012570128600_jphp12495-cit-0010","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/QAD.0000000000000112","article-title":"Interactions of tenofovir and tenofovir disoproxil fumarate with drug efflux transporters ABCB1, ABCG2, and ABCC2; role in transport across the placenta","volume":"28","author":"Neumanova","year":"2014","journal-title":"AIDS"},{"key":"2024103012570128600_jphp12495-cit-0011","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1128\/AAC.00671-07","article-title":"Effects of human immunodeficiency virus protease inhibitors on the intestinal absorption of tenofovir disoproxil fumarate in vitro","volume":"51","author":"Tong","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"2024103012570128600_jphp12495-cit-0012","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(02)00169-2","article-title":"Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview","volume":"55","author":"Schinkel","year":"2003","journal-title":"Adv Drug Deliv Rev"},{"key":"2024103012570128600_jphp12495-cit-0013","doi-asserted-by":"crossref","first-page":"736","DOI":"10.3109\/1061186X.2012.716847","article-title":"Pharmacotherapy in pregnancy; effect of ABC and SLC transporters on drug transport across the placenta and fetal drug exposure","volume":"20","author":"Staud","year":"2012","journal-title":"J Drug Target"},{"key":"2024103012570128600_jphp12495-cit-0014","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.toxlet.2010.04.025","article-title":"Efflux mechanisms at the developing brain barriers: ABC-transporters in the fetal and postnatal rat","volume":"197","author":"Ek","year":"2010","journal-title":"Toxicol Lett"},{"key":"2024103012570128600_jphp12495-cit-0015","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.toxlet.2008.03.007","article-title":"Role of breast cancer resistance protein (Bcrp\/Abcg2) in fetal protection during gestation in rat","volume":"178","author":"Cygalova","year":"2008","journal-title":"Toxicol Lett"},{"key":"2024103012570128600_jphp12495-cit-0016","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1128\/AAC.00251-06","article-title":"Mechanism of active renal tubular efflux of tenofovir","volume":"50","author":"Ray","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"2024103012570128600_jphp12495-cit-0017","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.bcp.2007.01.027","article-title":"Comparison of the inhibitory activity of anti-HIV drugs on P-glycoprotein","volume":"73","author":"Storch","year":"2007","journal-title":"Biochem Pharmacol"},{"key":"2024103012570128600_jphp12495-cit-0018","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1093\/jac\/dkl474","article-title":"Modulation of human BCRP (ABCG2) activity by anti-HIV drugs","volume":"59","author":"Weiss","year":"2007","journal-title":"J Antimicrob Chemother"},{"key":"2024103012570128600_jphp12495-cit-0019","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1128\/AAC.00733-08","article-title":"Combination of tenofovir and emtricitabine plus efavirenz: in vitro modulation of ABC transporter and intracellular drug accumulation","volume":"53","author":"Bousquet","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"2024103012570128600_jphp12495-cit-0020","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1097\/QAI.0b013e3181f52f0c","article-title":"Nuclear receptor-mediated induction of CYP450 by antiretrovirals: functional consequences of NR1I2 (PXR) polymorphisms and differential prevalence in whites and sub-Saharan Africans","volume":"55","author":"Svard","year":"2010","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2024103012570128600_jphp12495-cit-0021","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ejphar.2007.11.007","article-title":"Comparison of the induction of P-glycoprotein activity by nucleotide, nucleoside, and non-nucleoside reverse transcriptase inhibitors","volume":"579","author":"Weiss","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"2024103012570128600_jphp12495-cit-0022","doi-asserted-by":"crossref","first-page":"5914","DOI":"10.1128\/AAC.00544-11","article-title":"Pharmacokinetics and safety of single-dose tenofovir disoproxil fumarate and emtricitabine in HIV-1-infected pregnant women and their infants","volume":"55","author":"Flynn","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"2024103012570128600_jphp12495-cit-0023","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1136\/bmj.301.6746.259","article-title":"Fetal and placental size and risk of hypertension in adult life","volume":"301","author":"Barker","year":"1990","journal-title":"BMJ"},{"key":"2024103012570128600_jphp12495-cit-0024","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1079\/PNS19980016","article-title":"Maternal nutrition, placental growth and fetal programming","volume":"57","author":"Godfrey","year":"1998","journal-title":"Proc Nutr Soc"},{"key":"2024103012570128600_jphp12495-cit-0025","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1093\/ije\/dyl080","article-title":"The association between intrauterine growth restriction in the full-term infant and high blood pressure at age 7 years: results from the Collaborative Perinatal Project","volume":"35","author":"Hemachandra","year":"2006","journal-title":"Int J Epidemiol"},{"key":"2024103012570128600_jphp12495-cit-0026","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1097\/AOG.0b013e318212140e","article-title":"Fetal programming of adult disease: implications for prenatal care","volume":"117","author":"Lau","year":"2011","journal-title":"Obstet Gynecol"},{"key":"2024103012570128600_jphp12495-cit-0027","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1093\/aje\/kwp182","article-title":"Placental weight relative to birth weight and long-term cardiovascular mortality: findings from a cohort of 31,307 men and women","volume":"170","author":"Risnes","year":"2009","journal-title":"Am J Epidemiol"},{"key":"2024103012570128600_jphp12495-cit-0028","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s11010-009-0126-1","article-title":"COX-1 is coupled with mPGES-1 and ABCC4 in human cervix cancer cells","volume":"330","author":"Radilova","year":"2009","journal-title":"Mol Cell Biochem"},{"key":"2024103012570128600_jphp12495-cit-0029","doi-asserted-by":"crossref","first-page":"RESEARCH0034","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biol"},{"key":"2024103012570128600_jphp12495-cit-0030","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/sj.gene.6364190","article-title":"Real-time RT-PCR normalisation; strategies and considerations","volume":"6","author":"Huggett","year":"2005","journal-title":"Genes Immun"},{"key":"2024103012570128600_jphp12495-cit-0031","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.mce.2008.12.003","article-title":"Expression and activity of vitamin D receptor in the human placenta and in choriocarcinoma BeWo and JEG-3 cell lines","volume":"299","author":"Pospechova","year":"2009","journal-title":"Mol Cell Endocrinol"},{"key":"2024103012570128600_jphp12495-cit-0032","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"2024103012570128600_jphp12495-cit-0033","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/0006-3223(95)00598-6","article-title":"Leukocytes and organ-nonspecific autoantibodies in schizophrenics and their siblings: markers of vulnerability or disease?","volume":"40","author":"Zorrilla","year":"1996","journal-title":"Biol Psychiatry"},{"key":"2024103012570128600_jphp12495-cit-0034","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1097\/QAD.0b013e32833e1659","article-title":"Maternal and nenonatal tenofovir and emtricitabine to prevent vertical transmission of HIV-1: tolerance and resistance","volume":"24","author":"Group TEAS","year":"2010","journal-title":"AIDS"},{"key":"2024103012570128600_jphp12495-cit-0035","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1345\/aph.1L083","article-title":"Adverse effects of tenofovir use in HIV-infected pregnant women and their infants","volume":"42","author":"Nurutdinova","year":"2008","journal-title":"Ann Pharmacother"},{"key":"2024103012570128600_jphp12495-cit-0036","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1089\/apc.2008.0263","article-title":"Antiretroviral treatment in pregnancy: a six-year perspective on recent trends in prescription patterns, viral load suppression, and pregnancy outcomes","volume":"23","author":"Baroncelli","year":"2009","journal-title":"AIDS Patient Care STDS"},{"key":"2024103012570128600_jphp12495-cit-0037","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.reprotox.2008.09.010","article-title":"The ontogeny of drug metabolizing enzymes and transporters in the rat","volume":"26","author":"de Zwart","year":"2008","journal-title":"Reprod Toxicol"},{"key":"2024103012570128600_jphp12495-cit-0038","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/toxsci\/kfp149","article-title":"Are in vitro tests suitable for regulatory use?","volume":"111","author":"Hartung","year":"2009","journal-title":"Toxicol Sci"},{"key":"2024103012570128600_jphp12495-cit-0039","first-page":"600","article-title":"Administration of substances to laboratory animals: routes of administration and factors to consider","volume":"50","author":"Turner","year":"2011","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"2024103012570128600_jphp12495-cit-0040","doi-asserted-by":"crossref","first-page":"761","DOI":"10.33549\/physiolres.931319","article-title":"In vivo study of the effect of antiviral acyclic nucleotide phosphonate (R)-9-[2-(phosphonomethoxy)propyl]adenine (PMPA, tenofovir) and its prodrug tenofovir disoproxil fumarate on rat microsomal cytochrome P450","volume":"57","author":"Anzenbacherova","year":"2008","journal-title":"Physiol Res"},{"key":"2024103012570128600_jphp12495-cit-0041","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1046\/j.1440-169X.2003.00699.x","article-title":"Physiological regulation of P-glycoprotein, MRP1, MRP2 and cytochrome P450 3A2 during rat ontogeny","volume":"45","author":"Rosati","year":"2003","journal-title":"Dev Growth Differ"},{"key":"2024103012570128600_jphp12495-cit-0042","doi-asserted-by":"crossref","first-page":"959","DOI":"10.2165\/00003088-200241120-00003","article-title":"Ontogeny of hepatic and renal systemic clearance pathways in infants: part I","volume":"41","author":"Alcorn","year":"2002","journal-title":"Clin Pharmacokinet"},{"key":"2024103012570128600_jphp12495-cit-0043","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1124\/dmd.108.023721","article-title":"Tissue distribution, gender-divergent expression, ontogeny, and chemical induction of multidrug resistance transporter genes (Mdr1a, Mdr1b, Mdr2) in mice","volume":"37","author":"Cui","year":"2009","journal-title":"Drug Metab Dispos"},{"key":"2024103012570128600_jphp12495-cit-0044","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1124\/dmd.114.056929","article-title":"Ontogeny of human hepatic and intestinal transporter gene expression during childhood: age matters","volume":"42","author":"Mooij","year":"2014","journal-title":"Drug Metab Dispos"},{"key":"2024103012570128600_jphp12495-cit-0045","doi-asserted-by":"crossref","first-page":"3966","DOI":"10.1016\/j.febslet.2009.10.036","article-title":"Correlation of mRNA and protein in complex biological samples","volume":"583","author":"Maier","year":"2009","journal-title":"FEBS Lett"},{"key":"2024103012570128600_jphp12495-cit-0046","first-page":"3084","article-title":"P-glycoprotein, expressed in multidrug resistant cells, is not responsible for alterations in membrane fluidity or membrane potential","volume":"63","author":"Aleman","year":"2003","journal-title":"Cancer Res"},{"key":"2024103012570128600_jphp12495-cit-0047","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1158\/0008-5472.596.65.2","article-title":"Estrogen-mediated post transcriptional down-regulation of breast cancer resistance protein\/ABCG2","volume":"65","author":"Imai","year":"2005","journal-title":"Cancer Res"},{"key":"2024103012570128600_jphp12495-cit-0048","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature10098","article-title":"Global quantification of mammalian gene expression control","volume":"473","author":"Schwanhausser","year":"2011","journal-title":"Nature"},{"key":"2024103012570128600_jphp12495-cit-0049","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/bjp.2008.69","article-title":"Rifampin and digoxin induction of MDR1 expression and function in human intestinal (T84) epithelial cells","volume":"154","author":"Haslam","year":"2008","journal-title":"Br J Pharmacol"},{"key":"2024103012570128600_jphp12495-cit-0050","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1002\/jps.23549","article-title":"Estrogen receptor alpha induction by mitoxantrone increases Abcg2 expression in placental trophoblast cells","volume":"102","author":"Oda","year":"2013","journal-title":"J Pharm Sci"},{"key":"2024103012570128600_jphp12495-cit-0051","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1111\/aogs.12509","article-title":"Placental weight and placental weight to birthweight ratio in relation to Apgar score at birth: a population study of 522 360 singleton pregnancies","volume":"93","author":"Eskild","year":"2014","journal-title":"Acta Obstet Gynecol Scand"},{"key":"2024103012570128600_jphp12495-cit-0052","doi-asserted-by":"crossref","first-page":"4413","DOI":"10.1002\/jps.21744","article-title":"Comparison of bidirectional lamivudine and zidovudine transport using MDCK, MDCK-MDR1, and Caco-2 cell monolayers","volume":"98","author":"de Souza","year":"2009","journal-title":"J Pharm Sci"},{"key":"2024103012570128600_jphp12495-cit-0053","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1124\/dmd.108.020974","article-title":"Investigation of the role of breast cancer resistance protein (Bcrp\/Abcg2) on pharmacokinetics and central nervous system penetration of abacavir and zidovudine in the mouse","volume":"36","author":"Giri","year":"2008","journal-title":"Drug Metab Dispos"}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjphp.12495","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjphp.12495","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/68\/1\/84\/60231634\/jphp12495.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/68\/1\/84\/60231634\/jphp12495.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T18:29:24Z","timestamp":1730312964000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/68\/1\/84\/6128218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,1]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,1,1]]},"published-print":{"date-parts":[[2016,1,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jphp.12495","relation":{},"ISSN":["2042-7158","0022-3573"],"issn-type":[{"value":"2042-7158","type":"electronic"},{"value":"0022-3573","type":"print"}],"subject":[],"published-other":{"date-parts":[[2016,1]]},"published":{"date-parts":[[2016,1,1]]}}}