{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T12:30:34Z","timestamp":1779021034114,"version":"3.51.4"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The aim was to investigate the potential of self-microemulsifying drug delivery systems (SMEDDS) and niosomes as carriers for widening the gastrointestinal absorption window of furosemide (model acidic drug).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The drug was incorporated in SMEDDS and was encapsulated into niosomes. The intestinal absorption was monitored at two anatomical sites (duodenum and jejuno-ileum). This employed in situ rabbit intestinal perfusion technique.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>Perfusion of drug solution (control) revealed poor intestinal permeability with per cent fraction absorbed (%Fa) from the duodenum and jejuno-ileum being 1.3 and 0.6 % per cm, respectively. Formulation of furosemide as SMEDDS increased the %Fa from the duodenum and jejuno-ileum to reach 1.7 and 1 % per cm, respectively. Niosomal encapsulation increased the %Fa from duodenum and jejuno-ileum to record 1.9 and 1.2 % per cm, respectively. The increase in the %Fa was also revealed as a reduction in the length required for 95 % absorption of the drug which was reduced from 557.2 to 245.8 cm and to 279.8 cm after delivery as niosomes or SMEDDS, respectively, in case of jejuno-ileum. The same trend was recorded with the duodenum.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The recorded results highlighted the potential for SMEDDS and niosomes for widening the absorption window of acidic drugs after oral administration.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.12516","type":"journal-article","created":{"date-parts":[[2016,1,16]],"date-time":"2016-01-16T21:49:30Z","timestamp":1452980970000},"page":"324-332","source":"Crossref","is-referenced-by-count":42,"title":["Colloidal carriers for extended absorption window of furosemide"],"prefix":"10.1093","volume":"68","author":[{"given":"Amal A","family":"Sultan","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Technology, College of Pharmacy, University of Tanta , Tanta,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanaa A","family":"El-Gizawy","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, College of Pharmacy, University of Tanta , Tanta,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed A","family":"Osman","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, College of Pharmacy, University of Tanta , Tanta,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamal M","family":"El Maghraby","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, College of Pharmacy, University of Tanta , Tanta,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,3,1]]},"reference":[{"key":"2024103012552175700_jphp12516-cit-0001","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3109\/21691401.2013.800081","article-title":"Development and optimization of 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