{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:51:06Z","timestamp":1772999466646,"version":"3.50.1"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100012021","name":"Iran University of Medical Sciences","doi-asserted-by":"publisher","award":["21838"],"award-info":[{"award-number":["21838"]}],"id":[{"id":"10.13039\/100012021","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Cardiomyocyte hypertrophy is an important structural feature of diabetic cardiomyopathy. Calcineurin\/nuclear factor of activated T-cell (NFAT) pathway plays a central role in the pathogenesis of cardiac hypertrophy. The purpose of this study was to investigate the effects of tropisetron, a novel calcineurin inhibitor, on high glucose (HG)-induced cardiomyocyte hypertrophy and its underlying mechanism.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>H9c2 myocardial cells were treated with tropisetron or cyclosporine A 1 h before exposure to HG for 48 h.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>Exposure to HG resulted in enhanced cell size, protein content and atrial natriuretic peptide (ANP) protein expression. HG significantly increased Ca2+ level, calcineurin expression and nuclear translocation of NFATc4. Both tropisetron and cyclosporine A markedly prevented the hypertrophic characteristic features, calcineurin overexpression and nuclear localization of NFATc4 while intracellular Ca2+ was not affected.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our results showed that tropisetron may have protective effects against HG-induced cardiomyocyte hypertrophy. The mechanism responsible for this beneficial effect seems to be, at least in part, blockade of calcineurin\/NFAT signalling pathway.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/jphp.12522","type":"journal-article","created":{"date-parts":[[2016,3,6]],"date-time":"2016-03-06T07:47:46Z","timestamp":1457250466000},"page":"485-493","source":"Crossref","is-referenced-by-count":29,"title":["Tropisetron inhibits high glucose-induced calcineurin\/NFAT hypertrophic pathway in H9c2 myocardial cells"],"prefix":"10.1093","volume":"68","author":[{"given":"Firouzeh","family":"Asadi","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Iran University of Medical Sciences , Tehran,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Razmi","sequence":"additional","affiliation":[{"name":"Medicinal Plants Research Center, Institute of Medicinal Plants ACECR , 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